ID T1GFL2_MEGSC Unreviewed; 626 AA.
AC T1GFL2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3 {ECO:0000256|ARBA:ARBA00019787};
DE AltName: Full=Phosphoinositide-3-kinase class 3 {ECO:0000256|ARBA:ARBA00029930};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA002156-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA002156-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
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DR EMBL; CAQQ02189034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02189035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02189036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02189037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02189038; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1GFL2; -.
DR STRING; 36166.T1GFL2; -.
DR EnsemblMetazoa; MESCA002156-RA; MESCA002156-PA; MESCA002156.
DR HOGENOM; CLU_002191_1_2_1; -.
DR OMA; DECATIK; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR008290; PI3K_Vps34.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR PANTHER; PTHR10048:SF118; PI-3 KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00792; PI3K_C2; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR PIRSF; PIRSF000587; PI3K_Vps34; 3.
DR SMART; SM00142; PI3K_C2; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 25..187
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 216..397
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 465..626
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 626 AA; 72414 MW; 43C3F7D2450BB592 CRC64;
ENSQKSIENK IEEPLKEKYI SSWSINAEFK LTLHSIYDLN CDLSKYTDIC VYLGLFHADK
LLCSQKESSE KPIKNRESVK YEENIIFPIK LGDLPRMTKL CIVISERNKS IKLSKSKKIN
NKITGRPLAW TNATIFDYKG FLKSKELTLT TWTFADDNQY DDIFNPLGTV EANPRSDECA
TIKLTLDQYG FENNIKYPSE AEILKYSATV AKENLCKDRD EGSAQDTRSI NVVLTPYSKS
EKIEEMVDQD RNVIWSKRLD VLNGAHEELP ILLRCVNWNK KEEVAEMISL LKNWKLVSTE
RALELLDYSY PDPSIRKFAI SSLKQLEDEE LLLYLLQLAQ SIKHEAYLNC DLVIFLIERA
LKNQRIGHFF FWHLRSEMHV PCIQNKFGLI LEAFLKGTHI SQINAIQKQL EGFEKLKEGS
ELAKKGNKEK VKAVLQEFLG RRKFNDIFNK FQNPLNPSYS CKGIKVDCCK VMDSKMKPLW
IVFENLISSN DDISIIFKNG DDLRQDMLTL QMLKVMDKIW KNEGYDFRMN IYDCISMEKK
MGMIEVVLNA ETIANIQKKS RIFSATSPFK KGSIFAWIKE HNQTEDQLKK AIEEFTYSCA
GYCVATYVLG VADRHSDNIM IKKNGQ
//