ID T1GHW4_MEGSC Unreviewed; 447 AA.
AC T1GHW4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Adenomatous polyposis coli protein {ECO:0008006|Google:ProtNLM};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA003026-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA003026-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; CAQQ02038425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1GHW4; -.
DR STRING; 36166.T1GHW4; -.
DR EnsemblMetazoa; MESCA003026-RA; MESCA003026-PA; MESCA003026.
DR HOGENOM; CLU_613363_0_0_1; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR PANTHER; PTHR12607:SF12; APC-LIKE, ISOFORM A-RELATED; 1.
DR Pfam; PF05972; APC_15aa; 1.
DR Pfam; PF05923; APC_r; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 53..87
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 50174 MW; 986C964B29F7FAEB CRC64;
MKKMLHDIGT ITALTKAAMK NENENTLKAI LSALWNLSAH CSQNKAEFCS VDGSLSFLVT
MLQYEGPSKS LKITENAGGI LRNVSSHIAV SDTYRQILRE KNCLSILLQQ LKSESLTVVS
NSCGTLWNLS ARCPEDQKFL WDNGAVPMLR SLIHSKHKLI SEGSSAALKN LVNFRPGSIA
TNSMDSVAKS MGLKELPSLN ARKQKALEEV LDKNLSETCE NNEITTPLNE KKSFSSNFQC
KLYKGDDNLS KSKSSKLLMT SSSMEFELNG KKNDISNSAY RSREIILHIR RLIWINLQIL
ETDLDQPTNF SLRYTENENL DNEIEKNDDT IKCYQTEDTP YISKAPSIGD LRKDGKTEIF
TPEKPINYFE EGTPDKCSRR HSISSLDETM VAKPLKTNFG EPTEVECEQK KKPSNSALET
PLMFSRRSSM DSIEEDGKLV IDDKISE
//
