ID T1GN34_MEGSC Unreviewed; 649 AA.
AC T1GN34;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Sushi domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Megaselia scalaris (Humpbacked fly) (Phora scalaris).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea;
OC Phoridae; Megaseliini; Megaselia.
OX NCBI_TaxID=36166 {ECO:0000313|EnsemblMetazoa:MESCA004973-PA, ECO:0000313|Proteomes:UP000015102};
RN [1] {ECO:0000313|Proteomes:UP000015102}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Durham, NC isolate 2 -- Noor lab
RC {ECO:0000313|Proteomes:UP000015102};
RA Hughes D.;
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:MESCA004973-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; CAQQ02074680; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CAQQ02074681; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1GN34; -.
DR STRING; 36166.T1GN34; -.
DR EnsemblMetazoa; MESCA004973-RA; MESCA004973-PA; MESCA004973.
DR HOGENOM; CLU_422305_0_0_1; -.
DR Proteomes; UP000015102; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 4.10.410.20; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR InterPro; IPR001212; Somatomedin_B_dom.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF101; RT07201P-RELATED; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF01033; Somatomedin_B; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00201; SO; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF90188; Somatomedin B domain; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00524; SMB_1; 1.
DR PROSITE; PS50958; SMB_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015102};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..649
FT /note="Sushi domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004577036"
FT TRANSMEM 528..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..87
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 88..142
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 149..297
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 320..373
FT /note="SMB"
FT /evidence="ECO:0000259|PROSITE:PS50958"
FT REGION 383..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..649
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 72834 MW; 60CF2FB7B77C7816 CRC64;
MFKFLVLFLF IVICNGWRTG DNYSLSSPSS VSLCETPKPV FSQGLRPARK RGRLLQFDCM
RGYRMIGSKY LRCKNGKYDG DIPMCAKRGC EMPTRPENSI MLSEYHLSVL RLECNEGYTV
VGSRMSVCTG RNWTVPIGSC RETNTPSQLS CDFESEDFCG WTHDDDAEFK WKRHGHFMLA
ESRGQEINNK ARLISPVYNS NHSIGACVRL WYFMHGAAVE TLAIHFKTES VEMDSIIDST
DNVIWNVTRE SFDGWREAFA HLQEVTESFQ IIIEAQVSGS HLGDIAVDDF EIFPCSKDSV
EFSTESSDFT ESTDSILVVD FESCLDRCSE TESRQNTSKV TNTGVEVCDC HQNCVSLNSC
CPDYETKCLD EVLLGTTQIN DEGETTLPTT TTTVAPITNK PTTTTTTTTT TTTPAPTTRK
PITTTTTTTT KKPTTTTTTT TTTPTPATKR IITKPTTTTT TTTTKTTTST TPAPTTKRNI
PISTTSRTEI GTVTAISNRM FDVSTILLPD DENEPDDEGI YDLSVWQILL WSTISAIACF
SILFLLINFY KNKYRKFQNE DGFSNNSTKR NSDNSNQLSI RFNTREEQLD FRTAAEVEAG
ADPEQKPPIA DPQKVDESYS DDDDFVESEE RRKPYGKLSF PKNRKYSML
//
