ID T1H7Y9_RHOPR Unreviewed; 721 AA.
AC T1H7Y9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2023, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00012917};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
DE Flags: Fragment;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC000122-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC000122-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ACPB03000492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1H7Y9; -.
DR STRING; 13249.T1H7Y9; -.
DR EnsemblMetazoa; RPRC000122-RA; RPRC000122-PA; RPRC000122.
DR VEuPathDB; VectorBase:RPRC000122; -.
DR eggNOG; KOG2100; Eukaryota.
DR HOGENOM; CLU_014230_1_1_1; -.
DR InParanoid; T1H7Y9; -.
DR OrthoDB; 2877590at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT DOMAIN 101..269
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 506..716
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 721 AA; 80225 MW; 5A3A70F4C7979CBF CRC64;
MATKQVDKIV KVLQKVIRTP TPLSGRILNV CEDSATISTV WSQASPDREI TVHSETIHLV
DQKNKSVRNF GAIDTTTELL TSYSSSNNYR AVLRDVPSAS SKQNKRQVLE IWSKNTLWKS
FDLVKFEKHG DIYTDGEFGC LEWSPCETKL LYIAEKKTPK SEPFLGPGSK KSSEATIGTE
YDFIEDWGET LVGKSQPVVA ICDIETEAVE VISDATFEGP EAENVWSYGQ AVWAPDGASI
VCVAWDSTPR RLGLVYCTKR KSYIVHIKDV NSTKEIHRLS EDGRAVRSPV FAPDKSRLVW
LERDITGPHH ACHRIVKYEW DSKKRSVLVD VVDKEIKTEN GGLFYGIYCT SLNRPWLCDS
KTLLVSTPQR ASVRSFKIDT DNGNVIDISG SQTCDETFSE TVLDVSRDLV FCWRSAIGLT
PSLMLGCVNK SGVQDWITII PHSPSVVGYQ VDVIRLKASR TTDLVRDYSA VYFGPPLDSD
VKEVPLIVWP HGGPHSSSSN TYSLLYNFFA QLGFAILLVN YRGSIGAGQS SVDWLPGRVG
FSDVEDVHQA ALHVLHKYGS QLDPAKTVLF GGSHGGFLVL HLAGQYPSHY KAVATRNPVT
YIPPLSSTSD IPDWALVEGG FDYNPMKYEL SAEEHEAMRS KSPISHVGNV VSPILFLLGK
KDLRVPMSQG LDYYHALKAR NIKTRAIVYE DNHGLVKVPH LIDFAVNAAN WFLENIPHKL
S
//
