ID T1HB76_RHOPR Unreviewed; 806 AA.
AC T1HB76;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Elongator complex protein 2 {ECO:0000256|ARBA:ARBA00020267};
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC001283-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC001283-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA
CC biosynthesis. {ECO:0000256|ARBA:ARBA00005043}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat ELP2 family.
CC {ECO:0000256|ARBA:ARBA00005881}.
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DR EMBL; ACPB03009352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1HB76; -.
DR STRING; 13249.T1HB76; -.
DR EnsemblMetazoa; RPRC001283-RA; RPRC001283-PA; RPRC001283.
DR VEuPathDB; VectorBase:RPRC001283; -.
DR eggNOG; KOG1063; Eukaryota.
DR HOGENOM; CLU_006430_1_0_1; -.
DR InParanoid; T1HB76; -.
DR OMA; ENFRHIS; -.
DR OrthoDB; 22040at2759; -.
DR UniPathway; UPA00988; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0033588; C:elongator holoenzyme complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR037289; Elp2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44111; ELONGATOR COMPLEX PROTEIN 2; 1.
DR PANTHER; PTHR44111:SF1; ELONGATOR COMPLEX PROTEIN 2; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
SQ SEQUENCE 806 AA; 89666 MW; AFEA06CFE90DAA75 CRC64;
MLTEKLLNND TLETCYISSG CNRTPLSVDW GENNLVCYGS RNAVMIYKPE GKGGRRVIKT
LSSHKDRVNS VCWIRNTSDI CNTELVSAST DHTVIVWTLV KGEFLSTAHL LGHTGPVNAI
DAIYRKGNEP KSVVVVSASA QEFNCIETIS LKRGLCFCVQ IIVLTTVETP LLAFSTDTCH
VHLYLLGSQC TKLISLTGHE DWVRTIDFTN LGNGNVFLAT SSQDTTVRLW KISESSDEPD
DGSFKMSKLE FSVDSIKFSV GLESVLCGHE GWVYGLQWAP RNAGNTPTLM TASLDRTIIL
WSPHPESGVW LERVRMGELG GNTLGYFGCK FSPTGEHILA HSYQGSFHMW TNEQDQWKPA
VTIGGHFDSV VDLGWEKQGR YLLSTGLDQT TRLHAPWVQE SVDEVRATEL RIWSWHEMSR
PQVHGYAMNC IAVLPNFSFV SGAEEKVARA FKAPKNTLEN LSFLSNVQVE ESFLEGAESN
PTGAAVPSLG LSNQAVYTDK DLTEKQHPDN PKDEYSESYF IAQQFKEPAN DDALLQNTLW
PEVMKLYGHG YEVFSLAATN KGDFIASSCK ATTMDHAKIF LWNTNTWEKS DELPGHQLTI
TQMAFSPDDK YLLSVSRDRK WCLFEKQEFG KYTLKATTDK ATGVHSRIIW TCAWSHDGLY
FATGSREGKL AVWSVDGIAN CSASPPLNGV ILAGTPLDVK EAVTAAHFAP IHLISQTYLL
AVGCESGIIT LYSWSQQEPS WILLYSLDNI AHHMTVKKLQ FRPQLGRTGD ISENNSDILQ
LASASLDNSV KVYNINLSNL RKHITR
//
