ID   T1HDA2_RHOPR            Unreviewed;       967 AA.
AC   T1HDA2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=non-specific protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011903};
DE            EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC002018-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC002018-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
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DR   EMBL; ACPB03001074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1HDA2; -.
DR   STRING; 13249.T1HDA2; -.
DR   EnsemblMetazoa; RPRC002018-RA; RPRC002018-PA; RPRC002018.
DR   VEuPathDB; VectorBase:RPRC017853; -.
DR   eggNOG; KOG0199; Eukaryota.
DR   HOGENOM; CLU_306377_0_0_1; -.
DR   InParanoid; T1HDA2; -.
DR   OMA; LPECKPE; -.
DR   OrthoDB; 1614410at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IEA:UniProt.
DR   CDD; cd09539; SAM_TNK-like; 1.
DR   CDD; cd00174; SH3; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR049587; TNK-like_SAM.
DR   PANTHER; PTHR24418:SF444; ACTIVATED CDC42 KINASE-LIKE; 1.
DR   PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR   Pfam; PF00786; PBD; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 2.
DR   SMART; SM00285; PBD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50108; CRIB; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   967 AA;  106895 MW;  86EF2220399BFA24 CRC64;
     MTSKGPGLYE FLIEAELQQY FAGFKNDLKV QNVAQLKYVS DEDLQQLGMS KPEMRRLKKY
     FQKHFPQNYL SKFKKMILSR KEEQWECSLP DEPPDKPPIR VPNKHIIPAD AIIVNKELGT
     GEFGVVQQGV WTNDGERIQV AIKCLSRERM QNNPIEFLKE AAIMHAIDHE HIVRLYGVVL
     DTNALMLVTE LAALRSLLEC LKEPSLRASF PVLSLCHFAI QICDGMQYLE AKRLIHRCAP
     ECITYLKFTS ASDVWAYAVT LWEMFSYGFQ PWAALTGQQI LEAIDEPNPQ RLERPECCPK
     EYYSLMRKCW HHDPSRRPKF NDLMRQLPDC KPEQVQAIQD SGDERMKRDQ LIFRVGDIIT
     VLDKSPVQGT NLWKGVLNNG KTGVFNPALT VAYLGSNLPS NKPTEFIRGD GKNAYSSKRN
     RLRTDMISAP HGDVKHTGHV GLDGAYFGDI SFLGGTKYEH VPHQVVAPYK PHTDNEDTNS
     ISTDKAPLLG NITHTNGAGW ADTTSNSKLL TTDHEYHEIT DEEAVDSPGF EKQFDFGPSL
     LDEMDAAFRN YSSPPPPPPP PSSSSTCHSM VNEIVGNGSG TQHSNQHEQQ NKRNESLSAT
     SKKLATVSVK PISSSDEKTL DTAIALTYEL ANKVMVQQVQ QGPETSPNGR SNGSAGGGVN
     GGSGPHKSGS GSGGLTFKFP QVGGSGGGGN AGGNQSRGSH SRHEGRTFTD EAQAIPDVHA
     VFYNNEIRII SSCTSLESLR STTPFRLPLW DRASAEFCFA RSRDLLTRHP PKLDSSTEVL
     SGHSSGGSKK AWIDSSYNSS SNMLTLTSAT STSTLGGCPS LNDLNGGLIE KSSGSSRSSS
     TLKDIPSCNE FPAVTTAIPA PTFTTFGKTL PPPQNQTPKV HQHKRSASEV RQYPCSSGRA
     IPLLPPQNRR IHRYHSSIET RRWFADTRRY SSRYNGDTSS SSTSSTDSDY DSTRKGVCKN
     RKIIYLN
//