ID T1HK74_RHOPR Unreviewed; 551 AA.
AC T1HK74;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=glutaminase {ECO:0000256|ARBA:ARBA00012918};
DE EC=3.5.1.2 {ECO:0000256|ARBA:ARBA00012918};
DE Flags: Fragment;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC004447-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC004447-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-glutamine = L-glutamate + NH4(+);
CC Xref=Rhea:RHEA:15889, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359; EC=3.5.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001062};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SIMILARITY: Belongs to the glutaminase family.
CC {ECO:0000256|ARBA:ARBA00011076}.
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DR EMBL; ACPB03011909; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1HK74; -.
DR STRING; 13249.T1HK74; -.
DR EnsemblMetazoa; RPRC004447-RA; RPRC004447-PA; RPRC004447.
DR VEuPathDB; VectorBase:RPRC004447; -.
DR eggNOG; KOG0506; Eukaryota.
DR HOGENOM; CLU_016439_1_0_1; -.
DR InParanoid; T1HK74; -.
DR OMA; RWGNRPI; -.
DR OrthoDB; 537490at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR GO; GO:0004359; F:glutaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:InterPro.
DR Gene3D; 1.10.238.210; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR HAMAP; MF_00313; Glutaminase; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR015868; Glutaminase.
DR InterPro; IPR041541; Glutaminase_EF-hand.
DR NCBIfam; TIGR03814; Gln_ase; 1.
DR PANTHER; PTHR12544; GLUTAMINASE; 1.
DR PANTHER; PTHR12544:SF29; GLUTAMINASE; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF17959; EF-hand_14; 1.
DR Pfam; PF04960; Glutaminase; 1.
DR SMART; SM00248; ANK; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000015103};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..96
FT /note="Glutaminase EF-hand"
FT /evidence="ECO:0000259|Pfam:PF17959"
SQ SEQUENCE 551 AA; 61744 MW; 9EAD3441EE61CB32 CRC64;
DNTPSTEDML FDMFKTEDSD LLSVGKFLAA LRQTGLRKND PRLAGLMENL RIVHRESGRE
GGSPETQKLN REAFKRVISA NLILISRAFR HHFIIPDFSD FSKHIEEFYW KCKTNTEGKV
TSYIPQLARA NPDHWGVSVC TIDGQRFSIG DVTIPFTLQS TSKPLTYGIA LDQLGQEVVH
QYVGQEPSGR NFNELVLDHN KKPHNPMINA GAILVCSLLK TLIHPDMTLA EKFDFTMDYF
KRLAGGEYLG FNNAIFLSER EAADRNYALG FFMREHKCFP DKTNLKEAMD FYFQCCSMEA
NCESMSVMAA TLANGGICPV TEEKVLKPDS IRDVLSLMHS CGMYDYSGQF AFKVGLPAKS
GVSGGMLIVI PNVMGISTWS PPLDPLGNSC RGVQFCQELV SVFNFHRYDN LKHATNKKDP
RRHKYETKGL SIVNLLFSAA SGDVATLRRH RLSGLDMSLS DYDGRTALHL AAAEGHLDCV
SFLLEQCNVP YDIQDRWGNS PLDEAKTFGR VQVVQFINDW SQKHAAQPAK SEKIEGTVEK
PKISEDNSPL P
//
