ID   T1HY84_RHOPR            Unreviewed;       445 AA.
AC   T1HY84;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Legumain prodomain domain-containing protein {ECO:0000259|Pfam:PF20985};
OS   Rhodnius prolixus (Triatomid bug).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC   Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX   NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC009004-PA, ECO:0000313|Proteomes:UP000015103};
RN   [1] {ECO:0000313|Proteomes:UP000015103}
RP   NUCLEOTIDE SEQUENCE.
RA   Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL   Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:RPRC009004-PA}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (MAY-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   EMBL; ACPB03013281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; T1HY84; -.
DR   STRING; 13249.T1HY84; -.
DR   EnsemblMetazoa; RPRC009004-RA; RPRC009004-PA; RPRC009004.
DR   VEuPathDB; VectorBase:RPRC009004; -.
DR   eggNOG; KOG1348; Eukaryota.
DR   HOGENOM; CLU_024160_0_0_1; -.
DR   InParanoid; T1HY84; -.
DR   OMA; SKQWVLL; -.
DR   OrthoDB; 2951493at2759; -.
DR   Proteomes; UP000015103; Unassembled WGS sequence.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd21115; legumain_C; 1.
DR   Gene3D; 1.10.132.130; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR048501; Legum_prodom.
DR   InterPro; IPR046427; Legumain_prodom_sf.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF20985; Legum_prodom; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PIRSF; PIRSF019663; Legumain; 1.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT   DOMAIN          338..435
FT                   /note="Legumain prodomain"
FT                   /evidence="ECO:0000259|Pfam:PF20985"
SQ   SEQUENCE   445 AA;  50311 MW;  662070F91A633E42 CRC64;
     MYSLQLLGCF ILILVVSTYG FPSKPGGGKI WAFLVAGSDG YGNYRHQADV CHAYQILHSN
     GIPDENIIVM MADDIAYNSQ NPTPGVIINS PGGKDVYHGV PKDYTGKNVN PQTFLHVLTG
     NKSAVLGIGS GRVIESEPND HIFVNFVDHG GPGVLCFPDD DLAADDLIKA LKSMAHNSQF
     SKLVLYVEAC YSGSMFDNLL DDDLNIFVTT AADPFESSYA CYYDDKRNTY LGDFFSVNWM
     EDMSSESLVH NDLHHQFERV RTRTNTSHVE EYGDLDIGNT KLEDVLGLKK KSVNSVENEI
     KSEPMIDVFD NLHVPIQILK NQLEKYTDAS KRKELKTKLH TLEKKRSEVD SVVEKIINNL
     LDLDEDAKDE IRIGRHSLNK QNFPCYKKLY SLFSEKCFNL PKNPYVRIHL QKFINMCDIP
     SLDIEKAKEA IESVCYDPER YVNFF
//