ID T1I9V4_RHOPR Unreviewed; 645 AA.
AC T1I9V4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Acyl-CoA synthetase short-chain family member 3, mitochondrial {ECO:0000256|ARBA:ARBA00040004};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE AltName: Full=Acetate--CoA ligase 3 {ECO:0000256|ARBA:ARBA00042755};
DE Flags: Fragment;
OS Rhodnius prolixus (Triatomid bug).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Heteroptera; Panheteroptera;
OC Cimicomorpha; Reduviidae; Triatominae; Rhodnius.
OX NCBI_TaxID=13249 {ECO:0000313|EnsemblMetazoa:RPRC013075-PA, ECO:0000313|Proteomes:UP000015103};
RN [1] {ECO:0000313|Proteomes:UP000015103}
RP NUCLEOTIDE SEQUENCE.
RA Wilson R.K., Warren W., Dotson E., Oliveira P.L.;
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:RPRC013075-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (MAY-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + butanoate + CoA = AMP + butanoyl-CoA + diphosphate;
CC Xref=Rhea:RHEA:46172, ChEBI:CHEBI:17968, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371,
CC ChEBI:CHEBI:456215; Evidence={ECO:0000256|ARBA:ARBA00036650};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46173;
CC Evidence={ECO:0000256|ARBA:ARBA00036650};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; ACPB03017789; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ACPB03017790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ACPB03017791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ACPB03017792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ACPB03017793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1I9V4; -.
DR STRING; 13249.T1I9V4; -.
DR EnsemblMetazoa; RPRC013075-RA; RPRC013075-PA; RPRC013075.
DR VEuPathDB; VectorBase:RPRC013075; -.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_5_1; -.
DR InParanoid; T1I9V4; -.
DR OMA; FIMGRTD; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000015103; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015103}.
FT DOMAIN 9..63
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 217..454
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 518..596
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 645 AA; 71160 MW; 08A2EEF82CAE9421 CRC64;
IENGHSMHYL DMFRKSLEEP EKLWAEVGSV LDWYTPWSKV IDNTDEPFTK WYVGGELNAC
YNAVDRHVLA GKGNKVALIH DSPVTNSIRK VTYKELQEKI QTPEGGHILL GTLSSKSGTP
TYLIILFGSI PQLAAIITLG VACSILTQSS LAAKPKGYIL EEREKKQQVF SNKNISTLSV
QFSLNEAVTF SRFKPKICHI NFIKGKLSDN KNSSMDIDWD EALEASQPHP CVPVESNHPL
YILYTSGTTG QPKGVVRPTG SHLATLTWSM KSIYNMDSDK DVWWAASDMG WVVGHSYICY
GPLCAAVTSV MYEGKPDRTP HPGQYFRVVQ EHGVSGIFTA PTALRVIRKS DHSLQIGGNY
STKSLKYLFV AGEHCDHETK LWAEKAFKVP VLNHWWQTET GHAITANCVG LGHSLKPPKF
SAGLPVPGYD VRIVGEDGLE CPPGEQGRIV IKLPLPPGNM STLYKDTQHF LEIYFKKYPG
FYDTMDAGYR DENGYIYVLA RDDDIINVAG HRLSTAALED VILSHPDVAD GAVIGVPEFT
KGEIPLCLYV LKPGVTKEEE VVGEELVKLV RKLIGPIAAM KLCIAVSALP RTRSGKIARK
SLADLARNKA VVISSTIEDP SVYKEIKAAF QKVGYAKSAP DPQVA
//
