ID T1JB95_STRMM Unreviewed; 1541 AA.
AC T1JB95;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Protein-tyrosine-phosphatase {ECO:0008006|Google:ProtNLM};
OS Strigamia maritima (European centipede) (Geophilus maritimus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Geophilomorpha; Linotaeniidae; Strigamia.
OX NCBI_TaxID=126957 {ECO:0000313|EnsemblMetazoa:SMAR011033-PA, ECO:0000313|Proteomes:UP000014500};
RN [1] {ECO:0000313|Proteomes:UP000014500}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Brora {ECO:0000313|Proteomes:UP000014500};
RA Richards S.R., Qu J., Jiang H., Jhangiani S.N., Agravi P., Goodspeed R.,
RA Gross S., Mandapat C., Jackson L., Mathew T., Pu L., Thornton R., Saada N.,
RA Wilczek-Boney K.B., Lee S., Kovar C., Wu Y., Scherer S.E., Worley K.C.,
RA Muzny D.M., Gibbs R.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:SMAR011033-PA}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (FEB-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; JH432010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 126957.T1JB95; -.
DR EnsemblMetazoa; SMAR011033-RA; SMAR011033-PA; SMAR011033.
DR eggNOG; KOG0791; Eukaryota.
DR HOGENOM; CLU_001541_0_0_1; -.
DR OMA; QLITDTH; -.
DR OrthoDB; 5399547at2759; -.
DR PhylomeDB; T1JB95; -.
DR Proteomes; UP000014500; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 8.
DR CDD; cd14548; R3-PTPc; 1.
DR CDD; cd12087; TM_EGFR-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 7.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 11.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS50853; FN3; 7.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000014500};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1541
FT /note="Protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004580126"
FT TRANSMEM 1176..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..202
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 203..298
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 390..481
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 568..659
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 660..753
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 847..936
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 937..1034
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1255..1510
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1427..1501
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1517..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1541 AA; 174966 MW; EC47467FDBBE221B CRC64;
MTHLSSFPWL LAWVLLWLVL GFQCADVVIQ FLPDVANLGP DVLLRLNYNP PVGVPPANFT
FHPGDIKHQG ISITEALPGT EYIFQLYFSN KTVSDLLTWS DRLHTVPDEP TDFSLMSRTT
KTLQLKWDPP MRGGLSDYRL RVTPLTEPSK TSVRIIQIER DKVPFLLKDL TPGATYELKL
SAMFHNKESL GFISRNMTTK PNAPGRFIVW FRNETTLLVL WQPPYPAGVF NQYKASIEPR
DAVRSEVFVE KEIDPPGPAQ ADFNELIPGR NYNITVQTVS KGQLSAGTSA QYRTVPSPPR
NISFDKKLIK TDGFSVTWLP PKMPCEFERY HVSLGIRFKT SLIVDRDSER IATFNEGLEP
GRTYEIVVKT VSGNVASWPT TANVTTKPLP VTNLTATSLG KGVIHLSWSA NNSSIHDSFK
VYYQDVEAFN DDGGLAGVTK DTAFVLSSLL DGHNYSISVE AISNNVASDE VVIFQATIPV
SPIIKYLEPV RNGLNISWKS DVTSRQDSFE IVLIRNDTGE AFHRLTKEDR ILIDNLHAGA
SYEVKVYALS YGLKSEPHAF YQTVYPNPPQ NLTILSFGNA TVRLHWNPPK SSLYDYYIIK
YRGYGSLNSS WIEKGIVTNT TYDMMGLLPG NKYTIAIYTI SYRLESADAE KVELSLPPQA
VSGVNVALDS FNVTFSWSLP IGFVEQYVVM YSSTTNPTDL TTKIIPYNFT NTDKINVVIS
DLFPGELYHF QIYTVSHGAR SEPFLTQTRT KPRILSDVTT VVGNFETHSL SLRYTLTPNE
ASIFDRYHFE LNDTTVLSQE KLKNDTHRYL TFTGLTPGQL YDIIVWTVSG KIQSNPIKRQ
ERLYPEPISD MNATRITDSE ITLVWHPPQG EHSGYQVQYL QQDRLIQNET TIEKITFTNL
RPHKNYTFTV IVVSGSGTAH IRNSRPYSKH FATLEAAPGK VHFFRAKEIR PSEITLLWAL
PDFDQNGILL GFTVSFKKKN TKTFDKFEFP ADVTVGTIHN LTPGKTYIFM IEAKTKIGKG
PAVMLEETMP IWPPPTPNNQ IFPTDVAHTT TTIRIRFRKS YFSSAHGAVV AYTIIVVEDD
DKDSSGLELP TWYDVQTFAK WPAYQVNEPY NPFTNTTVEE FVIGTGGCVE TSRYCNGPLK
PGSQYKVKIR AFTARDKFTD TVYSQVISTE RDNTSIIVAA VLVPLMLLIG AILIIVLLRR
RRKTPFAKKT SKRNIAGKED SLSIPESIID TSRPSKLKEF PEHFRLMSAD SDFRFSEEYE
ELKMVGRDLP RTAADIPVNR PKNRFTNILP YDHSRVKLLP TDDEEGSDYI NANYVSGYNS
PREFIVTQGP LHSTRDDFWR MVWEQNCRAL VMLTRCIEKG REKCDHYWPY DTQPTTYGDI
QVTILNESQY ADWTISEFKV CRGDHSRVVR HFHFTTWPDF GVPDPPQSLI RFVRTFRERI
PSDQKPIVAH CSAGVGRSGT FIALDRILQH IQIHDYVDIF GIVYEMRKER VWMVQTEQQY
ICIHQCLLCV MEGRENENPP RAEAHENEGY EDDEGIAESG M
//
