ID   T1JVM9_TETUR            Unreviewed;       959 AA.
AC   T1JVM9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN   Name=107371553 {ECO:0000313|EnsemblMetazoa:tetur02g05180.1};
OS   Tetranychus urticae (Two-spotted spider mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC   Tetranychoidea; Tetranychidae; Tetranychus.
OX   NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur02g05180.1, ECO:0000313|Proteomes:UP000015104};
RN   [1] {ECO:0000313|Proteomes:UP000015104}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA   Rombauts S.;
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:tetur02g05180.1}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594}.
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DR   EMBL; CAEY01000795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015795161.1; XM_015939675.1.
DR   AlphaFoldDB; T1JVM9; -.
DR   STRING; 32264.T1JVM9; -.
DR   EnsemblMetazoa; tetur02g05180.1; tetur02g05180.1; tetur02g05180.
DR   GeneID; 107371553; -.
DR   KEGG; tut:107371553; -.
DR   eggNOG; KOG0433; Eukaryota.
DR   HOGENOM; CLU_001493_7_1_1; -.
DR   OMA; HCWRCKT; -.
DR   OrthoDB; 656at2759; -.
DR   Proteomes; UP000015104; Unassembled WGS sequence.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR   CDD; cd00818; IleRS_core; 1.
DR   Gene3D; 1.10.730.20; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033708; Anticodon_Ile_BEm.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015104}.
FT   DOMAIN          70..667
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          712..842
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   959 AA;  109743 MW;  3D33D05F7D39575F CRC64;
     MINVYSGPIK LIKWLNLFKS RSYCSSVSAK KWSKTVFIPA SDLPSRKAPK SEVDLLEKPC
     FYNLYRDQNG RPSDKLFVLH DGPPYANGSL HFGHVINKTL KDIICRYKIR QGYKVNFIPG
     WDCHGLPIEL KVYKEKGQSI PTDPLEIRQK ARKFAQSAID EQIKVFRRMG IAADWDNPYT
     TFSNEFVLNQ LQAFKTLYQK GLIHRSFLPI YFSPSNKTTL AESELEYNTN HTSPSIFFQF
     KVNHNLTLRT NHDIYALIWT TTPWTLPANQ AIAFSPKIEY IIVFASELSR YFIIAKENLL
     DLQSKLGTPL SVERTICNEE LSKLSYSHPM RLDSKQYLPF LSAEYVTSSK GTGLVHCAPN
     HGREDFDIAK KNGLSINNCI VDDNGNFVSG LHSELDGKSV LEGGSSLVMN LLKDEIVHKE
     DFVHSYPYDW RSGKPVIIKT SQQWFIDVGK VRDKCLSQLK TVNFFPSGIQ NKICDEISTR
     PPWCISRQRV WGVPIPVFYR KEDVNKSIPI VSSESIDYLI NKVKENGIEI WWSSPESELI
     PDQVCKSFGV NKEEIVAGRD IFDVWFDSGM TWNSVLAGDK IADIYLEGVD QCHGWFQTSL
     ILSIALRDLA PYKSVYVHGF AVDGDGRKMS KSVGNVIDPL PLIESKYGSD VMRLFVARYG
     SHHGNVKVDD EKLKTTMTLM LKFRNIFKFC LGSLRGFDSP GKLDYSKLNL INKYMLHQLW
     SFNQSCQKNY NDNDFRNIIT ESVSFIDDFS SFYLKIVKDS LYCDPLDSIG RSSCQSVIYY
     FLETFNNFLS PIIPFLFEEI NIIRKKDNKA ASCLLDGWFE CPSIWKNDQV SLIMGIIRLI
     KESIDNETED NKHFGKPFTA TIICHRKSDY ETLKTSESSS DNLEQQLSEI LQLSQVKLSQ
     SIDLESVEAD IKISCEESIP FTILLNKTNK SSCPRCRRYL SRLPNDLCHR CDAVISKHN
//