ID T1KD15_TETUR Unreviewed; 517 AA.
AC T1KD15;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Disks large 1 tumor suppressor protein {ECO:0008006|Google:ProtNLM};
OS Tetranychus urticae (Two-spotted spider mite).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Raphignathae;
OC Tetranychoidea; Tetranychidae; Tetranychus.
OX NCBI_TaxID=32264 {ECO:0000313|EnsemblMetazoa:tetur09g01330.1, ECO:0000313|Proteomes:UP000015104};
RN [1] {ECO:0000313|Proteomes:UP000015104}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=London {ECO:0000313|Proteomes:UP000015104};
RA Rombauts S.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:tetur09g01330.1}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; CAEY01002007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; T1KD15; -.
DR STRING; 32264.T1KD15; -.
DR EnsemblMetazoa; tetur09g01330.1; tetur09g01330.1; tetur09g01330.
DR eggNOG; KOG0708; Eukaryota.
DR HOGENOM; CLU_001715_4_1_1; -.
DR OMA; ACRVTSH; -.
DR Proteomes; UP000015104; Unassembled WGS sequence.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd11861; SH3_DLG-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF51; DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015104};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 51..132
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 162..232
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 326..501
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 272..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 58465 MW; EAA603D75230839C CRC64;
MVPTGYNMAP SPSIPDSNKP IDYSTTGQEI MNVVGGKLDK EIDYSTREPR TVVLTKSSTG
LGFNIVGGED GEGIFISFIL SGGPADLNGQ LRRGDQILSV NGFDLRHANH EQAAAALKGA
GQTVTLVVQY RPEEYNRFEA KIHDMREHII LNASGSLKTS IKRSFFVRAL FDYDPMKDSG
LPSRGLLFRF GDILHVINAS DDEWWQARRA LPDGQESELG IIPSRKRVEK KERARLKYVK
FQEKSGSDGK MSTIDRKKKN FSFSRKFPFM KSRDTEDESD ERDDRSPTKD QVESLSEADP
SNEVDNHKED NVLSYEYVIQ QEINYRRPVI ILGPLKDRIN DDLISEFPER FQSCVPHTTR
PPRDYEIDGR DYHFVASREQ MEKDIQNHLF IEAGQYNDNL YGTSVASVRS VAEAGKHCIL
DVSGSAIKRL QAAGLQPIAI FIKPRSISSL MDMNKRLAED EAKKLYERAM KLEQEFAEYF
TSIISGDTPE EIYAKVKSAI SVNDSSIIWV RPRDQGL
//
