ID T1PHQ6_MUSDO Unreviewed; 843 AA.
AC T1PHQ6;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=RhoGEF {ECO:0000313|EMBL:AFP62930.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP62930.1};
RN [1] {ECO:0000313|EMBL:AFP62930.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP62930.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP62930.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KA648301; AFP62930.1; -; mRNA.
DR AlphaFoldDB; T1PHQ6; -.
DR VEuPathDB; VectorBase:MDOA006201; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 448..639
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 687..819
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 95192 MW; 503CFB633103DCE1 CRC64;
MKDGLKEMPL EIKKSTPPTT PRSPTTTSGG FDANSFIGKL LEDPMLNQVA EGLEMDIVCE
LIENSLKRLQ ESRTTLDMSG TKDNDDMNRL IDLSLKRIRE ERQQAKNATV SPSANGNLLS
VPMVTKDEER LSNRGSISSA NSFASAHNYE LFDFEANESD CYQSCSSEIN SMLDDDIGSP
ETKSKFYQML VDATLQEIEL STNTEDLITD EHQYESIRHN CDPIYEEISD VPPPLPLTAP
PLNDPELEKK TARSIFEGAS KYDILSYLVD AKERGVVKEE VFDFPLNCSN PIIIEEESSD
TLSDLGKLSK LKRLDTISSR SSVLSDSSED NQSNLSSLSP PTNGGNNFSL LRHKHTSFSS
ASDIERNDSG VGSETSKTSR SKFLNPSHNS SITSSFSSTT SSTHSPQQRS SPLHLCEDCD
GPVETQLGED GIIFAPLVCR KCGKKRVERK EILTEIVETE EKYGRDLQII LEEFCHPMLV
AGLLTQEQLS AIFLNTEELL ENNQALAERM RDALDIALEQ GDDDLLTVNI GKIFLESTQM
LHAFESYCVR QAGASLLLAN LEKDKELLRI FLKVSQMENA VLRRMNLNSF LMVPVQRVTK
YPLLLARLYK VTPAHLEGRE LLKQAQEKIE LHLNHINQEA KDVPTKLWRR ISSSSPNRRA
SCEIDMINIK LRKMAIDVLE WNHDEVRFVM EGKLLYTQPT DSNWKKARTI KLTSANAMLV
TNGKPSTNYK AEKVMSDKLN FNKHTGIREA ALLLVKEKCG RYALIREPLY LDRCVVCSEA
DWDEYFEIQE ISSKDTFIFK AEDNVRTKQW YTQLQYHAQG MGAWRKRRNA LANIMINGML
TRS
//
