ID T1PKE0_MUSDO Unreviewed; 502 AA.
AC T1PKE0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Protein kinase {ECO:0000313|EMBL:AFP63798.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP63798.1};
RN [1] {ECO:0000313|EMBL:AFP63798.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP63798.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP63798.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KA649169; AFP63798.1; -; mRNA.
DR AlphaFoldDB; T1PKE0; -.
DR VEuPathDB; VectorBase:MDOA000259; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05589; STKc_PKN; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000961; AGC-kinase_C.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017892; Pkinase_C.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24351:SF242; PROTEIN KINASE C; 1.
DR PANTHER; PTHR24351; RIBOSOMAL PROTEIN S6 KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00433; Pkinase_C; 1.
DR SMART; SM00133; S_TK_X; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AFP63798.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 175..434
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 435..502
FT /note="AGC-kinase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51285"
FT REGION 82..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 204
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 502 AA; 57216 MW; 8C040D80CD47A4CD CRC64;
MPPSPAPIVE YPDDEDYSNY HRHYSIGAAD GFHVEVIPQF SNVSISNNNN NIQQQQQHSS
EPSPIIQEPQ TPIVYGGHLS ASEANAPHFP QPAQRQQNYQ PPSQQQQPQS SAVGQQQPIY
QNQFELQNAA AAAAAQANSR RNVARGLQYR DSAYESRRQS QNITAPPGIL SMDNFRMLSV
LGRGHFGKVI LCQLRTNNQY YAIKALKKGD IIARDEVESL LSEKRIFEVA NAMRHPFLVN
LYACFQTEQH VCFVMEYAAG GDLMMHIHTD VFSEPRAVFY AACVVLGLQY LHENKIIYRD
LKLDNLLLDT EGYVKIADFG LCKEGMGFGD RTGTFCGTPE FLAPEVLTET SYTRAVDWWG
LGVLIFEMLV GESPFPGDDE EEVFDSIVND EVRYPRFLSL EAIAIMRRLL RKNPERRLGS
SERDAEDVKR QAFFRSIVWD DLLLRRVRPP FVPTITHLED VSNFDEEFTS ERPQLTPPKE
PRVLTDEEQM FFQDFTYTAD WS
//
