ID T1PMA4_MUSDO Unreviewed; 994 AA.
AC T1PMA4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Ligand-gated ion channel {ECO:0000313|EMBL:AFP64541.1};
DE Flags: Fragment;
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP64541.1};
RN [1] {ECO:0000313|EMBL:AFP64541.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP64541.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP64541.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KA649912; AFP64541.1; -; mRNA.
DR AlphaFoldDB; T1PMA4; -.
DR VEuPathDB; VectorBase:MDOA004067; -.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd06382; PBP1_iGluR_Kainate; 1.
DR CDD; cd13714; PBP2_iGluR_Kainate; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF591; CLUMSY, ISOFORM B-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170}; Signal {ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..994
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004582978"
FT TRANSMEM 546..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..641
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..833
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 413..784
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 423..490
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 869..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 994
FT /evidence="ECO:0000313|EMBL:AFP64541.1"
SQ SEQUENCE 994 AA; 111916 MW; 870B07FE47923326 CRC64;
MQIYKFLLYL IFANLVKAKP KFNIGIILDA PRDDLEIAFL SAIDRSNINE RSFELEGVVV
YANAEDSFLV EKAACNLISQ NVIAIFGPIQ GSGSDIVASI CHTLEIPHFT FDWSPSEALD
EKPLRSMSLN LHPYNLQFSQ GLSETVQSFG WRSFTVVYES EKELQQIQDI LQIGEPSSNP
TTVKQLPDDS DYRPFLKSIK TSTDNCMILH CSLDKIMEIL RQADELKMLG EYQSIFIPTL
DTHTLDMQEI QNVGANITTI RLMDPTDYQL RNLVRDWEER EKREGNFYRV DVTQIKTNMV
LLSDAVWIFV KGLAELEIVE ELNPPEIACR RNRPWQQGRR ILEFIKARSD EAYTGRIDFN
QYGQRSFFTL RCMEVTQTGL LDLSTWDPVN GFGLLGADDD SDQRVGAKLQ NKTFIITSRL
GAPFLMEREA KDGEILEGNA RYEGYSLDLI DHIARLLNFK YEFHLAPDGR YGGFNKQTQK
WDGLVGQLLD GNADLGICDL TMTSARRKAV DFTPPFMTLG ISILYMKPEV QPANLFSFLL
PFSKDVWVYM ATGYLGVSLL LFFLARMAPE DWENPHPCKE PEEYENLWTI TNTTWLTMGS
IMGQGCDILP KASSTRLVTA IWWFFALMML NSYTANLAAF LTMSRMSSSI KSAEDLAAQN
KIKYGAVMGG STMNFFKESN FTTYQRMWAA MESDMTVFTR SNDEGVERVL KGKRLYAYLM
ESTGLEYIVE RKCNLTQIGG WLDYKTYGIA MPFNSPYRKQ ISGAVLKLGE AGTLTELKRK
WWKEMHGGGK CEKGEAASSD TAELDIESVG GVFLVLGLGL VCAFCIGIVE FLWNVKSVAV
DEKITLMEAL KVETLFALKF WITTKPVHAS SADSSDKSSS SSSSSSSSSS SSHSKSLKSV
GLSVSQSMKS MKSSIPETVR SSVHEKLRKI GSMFSIKSIK SEKADKEIET ATQQQLILVA
PPPMPRPLAI MRKSEIPIAD KAIQTEVKPK KHHH
//
