ID T1PNR9_MUSDO Unreviewed; 4154 AA.
AC T1PNR9;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Spectrin repeat protein {ECO:0000313|EMBL:AFP64227.1};
OS Musca domestica (House fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC Muscidae; Musca.
OX NCBI_TaxID=7370 {ECO:0000313|EMBL:AFP64227.1};
RN [1] {ECO:0000313|EMBL:AFP64227.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ALHF {ECO:0000313|EMBL:AFP64227.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:AFP64227.1};
RA Liu N., Zhang L., Li M., Reid W.;
RT "Transcriptome of adult Musca domestica launches a platform for comparative
RT house fly gene expression and characterization of differential gene
RT expression among resistant and susceptible house flies.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KA649598; AFP64227.1; -; mRNA.
DR VEuPathDB; VectorBase:MDOA013628; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.60; -; 23.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00435; Spectrin; 15.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 2.
DR SMART; SM00150; SPEC; 29.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 3.
DR SUPFAM; SSF46966; Spectrin repeat; 27.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 3728..3763
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 3764..3799
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 3804..3876
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 90..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 951..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2382..2416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3598..3668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3906..4154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1036..1067
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1336..1363
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1880..1907
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2200..2227
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 987..1015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2382..2404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3629..3657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3906..3927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3941..4098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4107..4141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4154 AA; 472404 MW; 860209E30D1C3B05 CRC64;
MSLEEAIKYN IIDPKTALVR DFDTFKFIPF EVAQQKGIVD LNKRTVVDPK ALYFAFDPTL
VIYVREPIQF EHAAEIKCLD LETGMLTYHD PVTKTPQSPE QHDVDEDSEG PTTTNEPVVY
TLKDATTLGI IDPDSALVKD LVKSKLVRLP EAFRKGLMDA NKANVLNTKT SKLCTLKEAY
ESGLIVTPKR SFGLLEAIAF NLYNPTNGCF VDPFQMNPDI IKRKKFTLAE AITAGLIDPS
STVVRNPSTG EIIPLTAAIQ NGLIDAHDGR ICDPNDSKTN MDLVKASEKG YLLAAEQRQA
VFEKFNMCEE NVNELLKWVY SIEHKIATVG GPREKIDELR NQINALKQIK DEIESQQRPV
ATCLEQIRQI VLTGGDVLSA PEVTTLENAG RELRSRVDRV NDRTVRLLRR LEAGRDELTK
LRSELDVFSE WLQSARRTLE DKERALSDLT RLSSQSESVR EFVSDVIGHQ ADLRFITMAA
QKFVDEGKEF LAILNDFRTS LPERLPHVEP LASSESPIRQ EVSLVSAQYK DLMNRVNALQ
DRISGLGGRQ REYQDALDKA NEWLRSTQPR VGRIIAEPIA GDPKSVQEQM NEAKALHNEL
LSNGRLVDNA QQALDSLLYT LGGQLSPMEI NQLEVPIADL KDKYQKLLDS LGEHCKTLDK
TLVQSQGVQE ALDNLGNWVN QAEDKFKLQL RPASLIKERL QEQIREHKAL LADMQSHQAS
IDSVESSAKH LMNTASNARI AKKVETNLND VTTKFDKLYD KVVKRGEFLD DVFNRLCKYL
DEISGVEQEI VTLQDALDSR DTSLLSAEEL AHRMQELSNR KESLSPAYED CIRNGKDLIS
IRDVTDTSTL RDRIKALESQ WRNINVSLDE KTKLSKQKAE HQVAYESLKD QVLSWLASTE
TRITELAPVA IDLEKIRQQN DELKPIYKDY RDYASTIDKI NDIGSQYDAL IRPESPGRKR
STFSPIKRVS PLRRMSGDAR SPSPTKGGIL SPLSTGSSGF GSRRSSQDGF QLSELSPVQQ
QLSEINNRYT LIGVRINDRQ NELDNMNEEV RKQFENLKNL AAFLERIQRQ LPKESVSNKD
EADRCIKQAR KILEDMYEKQ SLLDTTKTQI KDILRRKSDV PGAEQLRVEN DNIVEKWKQL
SDICKNRINF SEKLRDFLDT HNNLKNWLDS KERMLTVLGP ISSDPRMVQS QVQQVQVLRE
EFRTQQPQLK HFQEIGHDVL DHLEADSPDA SAVNKKLQDV NSKWEDLVGR LDERANSLGG
AADSSKEFDA AVNRLREALQ QISDNLDSLP SDGDHQDNLR KIENLERQLE GQRPLLADAE
QSAAALCNIL GDPASRADVN SRVAALEKQY QVLQKKLDTK KAETEATLRD GRHFAENCSK
TLGWLSAELS NLAERLLVSA HKPTLQHQID THEPIYREVM AREHEVIMLI NKGKDLTDRQ
QDRGVKRDLE RIQQQWEKLR REAVDRHTRL QTCMEHCKKY VSTSEVFLAW LRTAEDKLVD
LNPGVLSKSK LDTRLHDLHT FRSEVWKHSG EYENTKGLGE TFLSSCDVDK DPIKSELQDI
RERWERLNND LIARAQEIEN CSRRLGDFND ELRNLDHAVG RCEDRLAAHD ALGGAAKDPK
LLDRVKAIRE ELTNLQKPLQ TLKGMAKDIC AEARSAGGDA EHLTDDVDGI ADRIGELQSR
LDDRLGELQS AATAVSQFNE QIKNLGIDLN DLENEVEKLS PPAREIKRVQ GQIDDTYKLQ
TKLERIVERI EDGERAADAL VDAGFSPDTA QTREQISTLR KTLARLDNRV RDHSQLLEET
LRSLQEFYDM ESQTMDDIQD ISEEFRRMKP VGSELEQIRR QQEDFRNFRE NKIEPLAQNI
DKVNMAGRDL VRSAASGVST TQIEKDLEKL NDRWNDLKER MNERDRRLDV ALLQSGKFQE
ALAGLSKWLS DTEEMVANQK APSSDYKVVK AQLQEQKFLK RMLLDRQNSM SSLSSLGKEV
ANHCEPSERN AIEKQLHDLM KRFDALTDGA EQREKDLEEA MEVAKLFHDK ITPLELWLDN
TERAVKGMEL IPTDEEKIQQ RIREHGRLHD EILGKKPDFS DLADVAGQLM HLVSDEEAGN
LGEKVRTITD RYTGLVDASD NIGALLADSR QGLRHLVLTY QELVAWMERM ETELKRFRSV
PVFAEKLLEQ MDVLVELNEN IANHAPNVES TVDSGAELMK HISNDEAIQL KDKLDSLQRR
YGELTNRGGD LLNSAQNALP LVKQFHEAHT RLIDWMQVAE SALSTSEPRQ SDVLRLEAEL
VEMRPTLDCV NLVGPKLCQI SPGEGASTIE TIVTRDNRRF DAIVEQIQRK AERLHLSNQR
AKEVTNDIDE LLEWFREMDA NLREADPPAI EPKLVRAQLQ EHRSVNDDIS SQKGRVRDVT
AASKKVLRES PQSENTATLR EKLDDLKEIV DTVAQLCSER LGVLEQALPL SEHFADSHAG
LTTWLDDMEQ QLSRLSMPAL RPDQITQQQD KNERLLQSIA EHKPLLDKLN KTGEALGALV
ADDDSARINE ILDSDNARYA ALRLELRERQ QALDNALQES SQFSDKLEGM LRALANTVDQ
VNQLDPLSAL PQKIREQIED NDAIMDDLDK RTDAFSAVQR AASDVIAKAG NKSDPAVRDI
KSKLEKLNNL WNDVQKATKK RGSSLDDILN VAEPFWNQLQ SVMKTLKDLE ETLSSQEPPA
AQPQEIQKQQ VALQEIRHEI DQTKPEVEQV RRHGSNLMNL CGEPDKPEVK KHIEDLDNAW
DNITALYAKR EENLIDAMEK AMEFHETLQN LLKFLTKAED KFAHLGPVGS DIDAVKKQIE
QLKSFKDEVD PHMVEVEALN RQAVELTERT SPEQAASIRE PLAVVNRRWE ALLRGMVERQ
KQLEHALLHL GQFQHALNEL LVWISKTDGT LDQLKPIPGD PQLLEVELAK LKVLANDIQA
HQNSVDTLND AGRQLIESEK GSLEASTTQE KLRKLNQEWK MLLQKASDRQ HELEESLREA
QGYIAEVQDI LGWLGDVDAI IGASKPVGGL PETATEQLER FMEVYNELEE NRPKVETIQA
QGQEYIKRQN QMKVSSSNLQ HTLRTLKQRW DAVISRASDK KIKLEIALKE ATEFHDTLQA
FVEWLNQAEK QLANAQPVSR VLETIQVQME EHKVLQKDVS THREAMLLLD KKGTHLKYFS
QKQDVILIKN LLVSVQHRWE RIVSKAAERT RALDHGYKEA REFNDAWNNM MQYLQETETV
LDQIIEEATS SKDPQKIKKC IARLKDTHRQ LTGKQTLYDS TMRNGKNLME RAPKTDEAVL
GKMLCELKDQ WTRVLSKSIE RQRKLEEALL LSGQFSDALG ELLEWLKKAK QRLNEDGPVH
GDLETVQGLC EHHKHIEQDL QKRAAQMQGV LKTGRDLERS GNNPDVGRQL DELQTVWDEV
KSATAKRGDR LQVALKDAEK LNGSIQALFD WLDHAEHKLR YAKNAPDDEK ISREMMDMHI
EFMKDLHVRE QQKHETFEFA EDIIGKAYPD AIPIIKNWLS IIEERWEEVK QWAINREAKL
EQHLQSLKDL DDTIEELLAW LSGLEATLLN LERESLPDEI PPLEKLIEDH KEFMENTARR
QTEVDRACKP KQLPPGARKM SRTAKTPVRG SSHDIREQSP DGTLRRQSFK GSRDHGLNNR
KSSSVGPELE FRSTRAKLLW DKWRHVWMLS WERQRRLNDH LMYLKDLERV RNFSWDDWRK
RFLKHMNHKK SRLTDLFRKM DKDNNGLVPR GEFIDGILST KFDTSRMEMG AVADLFDRNG
EGLIDWQEFI AALRPDWQER KPQTDSDKIH DEVKRLVMLC TCRQKFRVFQ VGEGKYRFGD
SQKLRLVRIL RSTVMVRVGG GWVALDEFLQ KNDPCRAKGR TNIELREQFI LADGVSQSMA
SFTPKRAASV SAQNGNNNSN TPPYMSSQGP IIKVRERSGR SIPMTKQTRS SLSASTPDSL
SDNEGSHGNA SGRYTPRKVT YTSTRTGLTP GGSRAGSKPN SRPLSRQGSK PPSRHGSTLS
LDSTDEHTPS RIPQRKQSAA STISGTGTTP RPSRLSVTST TTTRTNGTTT ITRKTASGSA
SPAPTRNGGM SRSSSIPALT GYGYKPRRNI SGTSTPSGMQ TPRKSSAEPT FSSTMRSRTS
RGTTPVEKRE PFRL
//
