ID T1VYF0_9ALPH Unreviewed; 579 AA.
AC T1VYF0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Envelope glycoprotein E {ECO:0000256|ARBA:ARBA00013988};
GN Name=gE {ECO:0000313|EMBL:AGT95869.1};
OS Suid alphaherpesvirus 1.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Varicellovirus;
OC Varicellovirus suidalpha1.
OX NCBI_TaxID=10345 {ECO:0000313|EMBL:AGT95869.1};
RN [1] {ECO:0000313|EMBL:AGT95869.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NY {ECO:0000313|EMBL:AGT95869.1};
RA Gao X.-Y., Chen H.-Y., Ma S.-J., Chen L.-B., Guo G.-P., Liu Z.-Y.,
RA Kou Y.-N.;
RT "Sequence analysis and expression of the gE gene of pseudorabies virus
RT isolated in Henan Province of China.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:QEQ91676.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FJ-GSG5 {ECO:0000313|EMBL:QEQ91683.1}, FJ-N1
RC {ECO:0000313|EMBL:QEQ91676.1}, FJ-N2 {ECO:0000313|EMBL:QEQ91677.1},
RC FJ-N3 {ECO:0000313|EMBL:QEQ91678.1}, FJ-N4
RC {ECO:0000313|EMBL:QEQ91679.1}, FJ-SHS1 {ECO:0000313|EMBL:QEQ91682.1},
RC FJ-W2 {ECO:0000313|EMBL:QEQ91680.1}, and FJ-ZXF
RC {ECO:0000313|EMBL:QEQ91681.1};
RA Zhai X., Zhao W., Li K., Zhang C., Wang C., Su S., Zhou J., Lei J.,
RA Xing G., Sun H., Shi Z., Gu J.;
RT "Genome Characteristics and Evolution of Pseudorabies Virus Strains in
RT Eastern China from 2017 to 2019.";
RL Virol. Sin. 0:0-0(2019).
CC -!- FUNCTION: In epithelial cells, the heterodimer gE/gI is required for
CC the cell-to-cell spread of the virus, by sorting nascent virions to
CC cell junctions. Once the virus reaches the cell junctions, virus
CC particles can spread to adjacent cells extremely rapidly through
CC interactions with cellular receptors that accumulate at these
CC junctions. Implicated in basolateral spread in polarized cells. In
CC neuronal cells, gE/gI is essential for the anterograde spread of the
CC infection throughout the host nervous system. Together with US9, the
CC heterodimer gE/gI is involved in the sorting and transport of viral
CC structural components toward axon tips.
CC {ECO:0000256|ARBA:ARBA00025134}.
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Endosome membrane {ECO:0000256|ARBA:ARBA00004190}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004190}. Host Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004152}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004152}. Host cell junction
CC {ECO:0000256|ARBA:ARBA00004315}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004235}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004235}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein E family.
CC {ECO:0000256|ARBA:ARBA00008101}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KF130883; AGT95869.1; -; Genomic_DNA.
DR EMBL; MK610420; QEQ91676.1; -; Genomic_DNA.
DR EMBL; MK610421; QEQ91677.1; -; Genomic_DNA.
DR EMBL; MK610422; QEQ91678.1; -; Genomic_DNA.
DR EMBL; MK610423; QEQ91679.1; -; Genomic_DNA.
DR EMBL; MK610424; QEQ91680.1; -; Genomic_DNA.
DR EMBL; MK610425; QEQ91681.1; -; Genomic_DNA.
DR EMBL; MK610426; QEQ91682.1; -; Genomic_DNA.
DR EMBL; MK610427; QEQ91683.1; -; Genomic_DNA.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044156; C:host cell junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR003404; Herpes_glycopE_Fc.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF02480; Herpes_gE; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 3: Inferred from homology;
KW Host cell junction {ECO:0000256|ARBA:ARBA00023081};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 430..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 227..387
FT /note="Envelope glycoprotein E Fc-binding"
FT /evidence="ECO:0000259|Pfam:PF02480"
FT REGION 503..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 62869 MW; AE415BC50CDBA530 CRC64;
MRPFLLRAAQ LLALLALALS TEAPSLSAET TPGPVTEVPS PSAEVWDDLS TEADDDDLNG
DLDGDDRRAG FGSALASLRE APPAHLVNVS EGANFTLDAR GDGAVLAGIW TFLPVRGCDA
VSVTTVCFET ACHPDLVLGR ACVPEAPEMG IGDYLPPEVP RLRREPPIVT PERWSPHLSV
LRATPNDTGL YTLHDASGPR AVFFVAVGDR PPAPADPVGP ARHEPRFHAL GFHSQLFSPG
DTFDLMPRVV SDMGDSRENF TATLDWYYAR APPRCLLYYV YEPCIYHPRA PECLRPVDPA
CSFTSPARAR LVARRAYASC SPLLGDRWLT ACPFDAFGEE VHTNATADES GLYVLVMTHN
GHVATWDYTL VATAAEYVTV IKELMAPARA PGTPWGPGGG DDAIYVDGVT TPAPPARPWN
PYGRTTPGRL FVLALGSFVM TCVVGGAIWL CVLCSRRRAA SRPFRVPTRA RTHMLSPVYT
SLPTHEDYYD GDDDDDEEAG VIRRRPASPS GDSGYEGPYA SLDPEDEFSS DEDDGLYVRP
EEAPRSGFDV WFRDPEKPEV TNGPNYGVTA NRLLMSRPA
//
