ID T1WGP4_CITSI Unreviewed; 1558 AA.
AC T1WGP4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=DNA (cytosine-5)-methyltransferase {ECO:0000256|PIRNR:PIRNR037404};
DE EC=2.1.1.37 {ECO:0000256|PIRNR:PIRNR037404};
OS Citrus sinensis (Sweet orange) (Citrus aurantium var. sinensis).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX NCBI_TaxID=2711 {ECO:0000313|EMBL:AGU16981.1};
RN [1] {ECO:0000313|EMBL:AGU16981.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu J.D.;
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGU16981.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu J., Xu H., Xu Q., Deng X.;
RT "Characterization of DNA Methylation Variations During Fruit Development
RT and Ripening of Sweet Orange.";
RL Plant Mol. Biol. Rep. 33:1-11(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|PIRNR:PIRNR037404,
CC ECO:0000256|RuleBase:RU000417};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037404}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family.
CC {ECO:0000256|PIRNR:PIRNR037404, ECO:0000256|PROSITE-ProRule:PRU01016,
CC ECO:0000256|RuleBase:RU000416}.
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DR EMBL; KF032905; AGU16981.1; -; mRNA.
DR RefSeq; NP_001275841.1; NM_001288912.1.
DR GeneID; 102616428; -.
DR KEGG; cit:102616428; -.
DR OrthoDB; 317994at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR CDD; cd04712; BAH_DCM_I; 1.
DR CDD; cd04708; BAH_plantDCM_II; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR022702; Cytosine_MeTrfase1_RFD.
DR InterPro; IPR017198; DNMT1-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00145; DNA_methylase; 1.
DR Pfam; PF12047; DNMT1-RFD; 2.
DR PIRSF; PIRSF037404; DNMT1; 5.
DR PRINTS; PR00105; C5METTRFRASE.
DR SMART; SM00439; BAH; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037404};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|PIRNR:PIRNR037404};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037404};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PIRNR:PIRNR037404};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037404}.
FT DOMAIN 762..896
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 935..1075
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..713
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1226
FT /evidence="ECO:0000256|PIRSR:PIRSR037404-1,
FT ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 1558 AA; 175531 MW; 6471F7E1200DC097 CRC64;
MGSAALLDSK ESNDQKATDS SEMKNKKRKP KSEVPETKDS TSGQKEKMKK LSQDSEEPRK
RPKRMAACTD FKEKSVRISE KSFLVEAKKD QYADDEIVAV GLTARQDGDR PNRRLSDFIL
HDENGLPQPL EMLEIDDLFI SGLILPLQES SDREKEKGVR CEGFGRIESW SISGYEDGSP
VIWLSTDIAD YDCLKPASSY KKYYELFFEK ARACIEVYKK LSKASGGNSD CSLDELLAGV
VRSMSGSKCF RGGVSIKDFV ISQGEFIFNQ LIGLDETSKK NDQKFAELTV LVALKEESSK
RENFVQVNAA SLGGNLAIGS KVGDGDGKMD QYGSSTCPAD EDEDAKLARL LQEEELWQSK
KQKKTQGSTS GMNKFYIKIN EDEIANDYPF PVFYRPSEEE FDELLAYDSD YDSCDIDQLP
RRMLHDWSLY NSDSRLISLE LLPMKPCEDI DVTIFGSGKM TSDEGSGFCL DTDSSQCTSG
VSGAQDAGGF PIYLSSIKEW MIEFGSSMIF ISIRTDLAWY RLGKPSKQYA PWYEPVLKTA
RVAISIITML KEQTRVSRLS FTDVIKRLSE LKKDQHSYIS SDPAAVERYV VVHGQIVLQL
FAEYPDEQIK KCAFIIGLMK KMEERHHTKW LVKKKKVQKS EINLNPRASM GPVVVSKRKV
MQATTTRLIN RIWGEYYSNY SPEDGKEETA CEANEDEEVE EQGENEEDDT EEEKLISEER
QISCSVAVQI KSRSTKKEIT WEGECVRKSG LALYKKAIVH GEVVSVGSAV LVEVDEMDQL
PVIYFVEYMF EATGGCKLFH GIIMQRGSHT VLGNTANERE VFLANQCRDL ELQDIKQTVV
VDIRSVPWGH QHRKDIANAD KVDRARAEER KKKGLPTEYY CKSLYWPERG AFFILPVDSM
GLGVGSCHAC GTKESEKEKE TFKVHSKTSF VYGTAEYFVH DYVYISPHHF TWDKAEGETF
KAGRNVGLKP YVVCQLLEII VPKEPKRAEV KSTQVKVRRF FRPDDISAEK AYCSDIREVY
YSEETHLIFV EAIAGKCEVR KKNDIPACNA PAIFQHIFFC EHLYDPSKGS LKQLPAHIKL
RYSSGSLDSE AASRRKKGKC IEGEDELEVE KQGGASQENH LATLDIFAGC GGLSEGLQQS
GISSTKWAIE YEEPAGEAFK LNHPESLMLI NNCNVILRAV MEKCGDAEDC VSTSEAAELV
ASLDENVINN LPLPGQVDFI NGGPPCQGFS GMNRFNQSTW SKVQCEMILA FLSFADYFRP
RYFLLENVRN FVSFNKGQTF RLTLASLLEM GYQVRFGILE AGAFGVSQSR KRAFIWAASP
HDTLPEWPEP MHVFAAPELK IMLSDNYQYS AVRSTANGAP FRAMTVRDTI GDLPAVGNGA
SKTIMEYQND PVSWFQKRIR GNMAVLTDHI SKEMNELNLI RCQKIPKRPG ADWHDLPDEK
VKLSTGQVVD LIPWCLPNTA KRHNQWKGLF GRLDWEGNFP TSITDPQPMG KVGMCFHPDQ
DRILTVRECA RSQGFPDSYQ FHGSIQHKHR QIGNAVPPTL AFALGRKLKE AVESKRST
//
