ID T2F972_MACFA Unreviewed; 729 AA.
AC T2F972;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 08-NOV-2023, entry version 32.
DE SubName: Full=Gamma-interferon-inducible protein 16 {ECO:0000313|EMBL:AGV74415.1};
GN Name=IFI16 {ECO:0000313|EMBL:AGV74415.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|EMBL:AGV74415.1};
RN [1] {ECO:0000313|EMBL:AGV74415.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24682156;
RA Cagliani R., Forni D., Biasin M., Comabella M., Guerini F.R., Riva S.,
RA Pozzoli U., Agliardi C., Caputo D., Malhotra S., Montalban X., Bresolin N.,
RA Clerici M., Sironi M.;
RT "Ancient and recent selective pressures shaped genetic diversity at AIM2-
RT like nucleic acid sensors.";
RL Genome Biol. Evol. 6:830-845(2014).
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DR EMBL; KF154419; AGV74415.1; -; mRNA.
DR RefSeq; NP_001306378.1; NM_001319449.1.
DR AlphaFoldDB; T2F972; -.
DR OrthoDB; 4893941at2759; -.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF5; GAMMA-INTERFERON-INDUCIBLE PROTEIN 16; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 4.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 2.
PE 2: Evidence at transcript level;
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 189..389
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 506..705
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 89..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 81670 MW; 66EC30FD47B171EF CRC64;
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS KDLKLNVKMR EEYDKIQIAD LMEEKFRGDA
GLGKLIQIFK DIPTLEDLAE TLRKEKLKVK QLAPSRKRKN EVDPASPAPS TSGTVNTEGA
EATPGAQKRK KPTKEKAGTK GSKMSEEQTQ PPCPAGAGLS AAVGHSPPPK TSSSAPPNTS
SAENPKTVAK CPVTPRKNIL QKGPVIVKVL STTKPFEYET PEMEKKTMFH ATVATQTQFF
HVKVLNTNLK EKFNGKKIIV ISDYLEYDSL LEVNEESSVS EAGPNQMFEV PNKIINRAKE
TLKTDILHKQ ASGNIIYGIF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD
KLQLYCFRLR KKNQMSKLIS EMHSFIQVKK KPNPKNNDPK SMKPPQEQSQ LPNPSEAGKT
FPESHLQTPQ MPPTTPSSSF FIKKSEDTIT KMNDLMRMQI LKEKSHFPGP FMTSIGPADS
HLHTPQMLPS IPSSSCLTML TPRLKTGPEE VSTLDGVQSD LKEVMVLNAT ESFVYEPIEQ
KKMFHATVAT ENEVFRVKVF NIDLKEKFTP KKIIAISNYV CRSGFLEVYP LTVVVDVNAD
RKMEIPQGLI RSANTTPKIS YLCSQTKGSF VNGVFEVHKK NVRGEFTYYE IQDNTGKMEV
VVHGRLTTIN CEEGDKLKLT CFELAPKSGN NGELRSVIHS HIKVIKARKN KKDIFNPDSS
METSPGFFF
//
