ID T2HQS4_9ORTO Unreviewed; 335 AA.
AC T2HQS4;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=sialate O-acetylesterase {ECO:0000256|ARBA:ARBA00013141};
DE EC=3.1.1.53 {ECO:0000256|ARBA:ARBA00013141};
DE Flags: Fragment;
GN Name=HE {ECO:0000313|EMBL:BAN82482.1};
OS Influenza C virus (C/Mie/199/2012egg).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Insthoviricetes; Articulavirales; Orthomyxoviridae; Gammainfluenzavirus;
OC Gammainfluenzavirus influenzae; Influenza C virus.
OX NCBI_TaxID=1236553 {ECO:0000313|EMBL:BAN82482.1};
RN [1] {ECO:0000313|EMBL:BAN82482.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C/Mie/199/2012egg {ECO:0000313|EMBL:BAN82482.1};
RA Yano T., Maeda C., Akachi S., Matsuno Y., Yamadera M., Kobayashi T.,
RA Nagai Y., Iwade Y., Kusuhara H., Katayama M., Fukuta M., Nakagawa Y.,
RA Naraya S., Takahashi H., Hiraoka M., Yamauchi A., Nishinaka T., Amano H.,
RA Yamaguchi T., Ochiai H., Ihara T., Matsuzaki Y.;
RT "Phylogenetic Analysis and Seroprevalence of Influenza C Virus in Mie
RT Prefecture, Japan in 2012.";
RL Jpn. J. Infect. Dis. 67:127-131(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-4-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:25564, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29006, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00000954};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-acetyl-9-O-acetylneuraminate = acetate + H(+) + N-
CC acetylneuraminate; Xref=Rhea:RHEA:22600, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:28999, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:35418; EC=3.1.1.53;
CC Evidence={ECO:0000256|ARBA:ARBA00001221};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Host cell membrane {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I
CC membrane protein {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the influenza type C/coronaviruses
CC hemagglutinin-esterase family. {ECO:0000256|ARBA:ARBA00010920}.
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DR EMBL; AB751596; BAN82482.1; -; Viral_cRNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR GO; GO:0001681; F:sialate O-acetylesterase activity; IEA:UniProtKB-EC.
DR GO; GO:0039654; P:fusion of virus membrane with host endosome membrane; IEA:UniProtKB-KW.
DR GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.20.70.20; -; 1.
DR InterPro; IPR008980; Capsid_hemagglutn.
DR InterPro; IPR007142; Hemagglutn-estrase_core.
DR InterPro; IPR003860; Hemagglutn-estrase_hemagglutn.
DR Pfam; PF03996; Hema_esterase; 1.
DR Pfam; PF02710; Hema_HEFG; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF49818; Viral protein domain; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host endosomal membrane
KW {ECO:0000256|ARBA:ARBA00022510};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|ARBA:ARBA00022506};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemagglutinin {ECO:0000256|ARBA:ARBA00022546};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral envelope protein {ECO:0000256|ARBA:ARBA00022879};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 25..332
FT /note="Haemagglutinin-esterase glycoprotein core"
FT /evidence="ECO:0000259|Pfam:PF03996"
FT DOMAIN 137..290
FT /note="Haemagglutinin-esterase glycoprotein haemagglutinin"
FT /evidence="ECO:0000259|Pfam:PF02710"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAN82482.1"
FT NON_TER 335
FT /evidence="ECO:0000313|EMBL:BAN82482.1"
SQ SEQUENCE 335 AA; 37375 MW; 2FB1807E7443E59C CRC64;
EKIKICLQKQ VNSSFSLHNG FGGNLYATEE KRMFELVKPK AGASVLNQST WIGFGDSRTD
KTNSAFPRSA DVSAKTADKF RSLSGGSLML SMFGPPGKVD YLYQGCGKHK VFYEGVNWSP
HAAIDCYSKN WTDIKLNFQK NIYELASKSH CMSLVNALDK TIPLHVTAGT AKNCNNSFLK
NPALYTQEVK PSEDKCGKEN LAFFTLPTQF GTYECKLHLV ASCYFIYDSK EVYNKRGCDN
YFQVIYDSSG KVVGGLDNRV SPYTGNSGDT PTMQCDMIQL KPGRYSVRSS PRFLLMPERS
YCFDMKEKGP VTAIQSIWGK GRKSDYAVDQ ACLXT
//
