ID   T2HR77_HBV              Unreviewed;       279 AA.
AC   T2HR77;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Polymerase {ECO:0000313|EMBL:BAN82637.2};
DE   Flags: Fragment;
GN   Name=S {ECO:0000313|EMBL:BAN82637.2};
GN   Synonyms=preS2 {ECO:0000313|EMBL:BAN82637.2};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:BAN82637.2};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:BAN82637.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KE20404 {ECO:0000313|EMBL:BAN82637.2};
RA   Kwange S.O., Budambula N.L.M., Kiptoo M.K., Okoth F., Ochwoto M., Oduor M.,
RA   Kimotho J.H.;
RT   "Hepatitis B virus subgenotype A1, occurrence of subgenotype D4, and S gene
RT   mutations among voluntary blood donors in Kenya.";
RL   Virus Genes 0:0-0(2013).
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DR   EMBL; AB786646; BAN82637.2; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          55..279
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAN82637.2"
FT   NON_TER         279
FT                   /evidence="ECO:0000313|EMBL:BAN82637.2"
SQ   SEQUENCE   279 AA;  31334 MW;  A37567E75093EF9E CRC64;
     EFHSFPPSSA RSQSQGPVFS CWWLQFRNTQ PCSKYCLSHL VNLLEDWGPC AEHGEHHIRI
     PRTPARVTGG VFLVDKNPHN TAESRLVVDF SQFSRGITRV SWPKFAVPNL QSLTNLLSSN
     LSWLSLDVSA AFYHIPLHPA AMPHLLIGSS GLSRYVARLS SNSRIHNNQH GTLQNLHDSC
     SRQLYVSLML LYKTYGWKLH LYSHPIILGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP
     HCLAFSYMDD VVLGAKSVQH LESLYTAVTN FLLSLGIHL
//