ID T2M2Z5_HYDVU Unreviewed; 810 AA.
AC T2M2Z5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Tudor and KH domain-containing protein {ECO:0000313|EMBL:CDG66436.1, ECO:0000313|RefSeq:XP_012557746.1};
GN Name=TDRKH {ECO:0000313|EMBL:CDG66436.1};
GN Synonyms=LOC101236710 {ECO:0000313|RefSeq:XP_012557746.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG66436.1};
RN [1] {ECO:0000313|EMBL:CDG66436.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG66436.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
RN [2] {ECO:0000313|RefSeq:XP_012557746.1}
RP IDENTIFICATION.
RC STRAIN=105 {ECO:0000313|RefSeq:XP_012557746.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; HAAD01000204; CDG66436.1; -; mRNA.
DR RefSeq; XP_012557746.1; XM_012702292.1.
DR EnsemblMetazoa; XM_012702292.1; XP_012557746.1; LOC101236710.
DR GeneID; 101236710; -.
DR KEGG; hmg:101236710; -.
DR OrthoDB; 375531at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR22948:SF75; FI20010P1; 1.
DR PANTHER; PTHR22948; TUDOR DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50304; TUDOR; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000694840};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 329..390
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 606..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 91707 MW; EF99C9C28AAE92D9 CRC64;
MNSHQEKYIL IACISSAVVL ASIYFLYRKK KNTRKYNHDE NNEVVKFTDL NSQDNNVSDF
QTKKVVKVPS HIVGSIIGKN GTNINYLKSY FGVRLDFKNK EENDLINDQE NLASNKTIDE
KLKERTLVIT GNYEQVQAAE EHVKKLILEA PPIIEAEILV PQSSCGRIIG KGGQNIREMC
NTSGAKIIVN KDQDISIGDQ CRVRITGTKT QVDDAILLVK KKVSQEAEFN KKNKTDENIK
KENADFTRNK QFDQIQNVIE LPLSNIQKPL ESLQLPINEY FKVFVSAFET PEHIWVQYLH
SESQSLDALI KEMTELYGGK QSQIARLEKG TIGDICVAPF DNDSGEMFRA CIKSVNLDSR
TVELFYIDFG DTGYQDIDQL KQIRSEHLVL PPQAVECYLP ISAKDSDWSD EALEHFENIV
HCSQWLPLVA KVIGYKNTDT AKYPILQLVD STEEKELHIC DDMVQKGYAI DLSKHFIEND
GLLTTLDHPN NNEYAYFEFE TCLSNVKPAD VKGVQEDICN ELDSGNVFHE NLKFSENHTD
ETNHQRTIFE DCFEEKQNRD QHLENQFLDD DEFIINTPNK VTEQLEECGI INSLMSGVAI
QNKTSSESST DSLCNIPTPK STSSRHSSDD FVNINDNTLS GAILSVVNEH LSDNLNRDEE
FKELNGDISK SSEEIIVNEF TELQKSLEET SRKNVKSMEF TSDDDDDTGS FFSARSEVTI
TDIEDVNAED LSTIESDISV NIPDFSSVEL LEAKSINDFY DSMHDSLSKG PVYTQKNGLP
YSIQVIDEKK KMGLSSESNK VSSKDHINGF
//
