ID T2M515_HYDVU Unreviewed; 353 AA.
AC T2M515;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN Name=GPN1 {ECO:0000313|EMBL:CDG67209.1};
GN Synonyms=LOC100197776 {ECO:0000313|RefSeq:XP_002160539.2};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG67209.1};
RN [1] {ECO:0000313|EMBL:CDG67209.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG67209.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
RN [2] {ECO:0000313|RefSeq:XP_002160539.2}
RP IDENTIFICATION.
RC STRAIN=105 {ECO:0000313|RefSeq:XP_002160539.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; HAAD01000977; CDG67209.1; -; mRNA.
DR RefSeq; XP_002160539.2; XM_002160503.3.
DR EnsemblMetazoa; XM_002160503.3; XP_002160539.2; LOC100197776.
DR EnsemblMetazoa; XM_002160503.4; XP_002160539.2; LOC100197776.
DR GeneID; 100197776; -.
DR KEGG; hmg:100197776; -.
DR OMA; MIIVFNK; -.
DR OrthoDB; 5475185at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd17870; GPN1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059};
KW Reference proteome {ECO:0000313|Proteomes:UP000694840}.
FT REGION 293..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 39732 MW; D0F216D6FE1360F9 CRC64;
MACAVENEIS EELKSIKIDE KHEMPCILVL GMAGSGKTTF VQRLTSYLYS KKTPPYVINL
DPAVHEIPYP ANIDIRDTVD YKEVMKQYNL GPNGAIMTSL NLFVTKFDQV LNFVENKNNE
YSSIIIDTPG QIEVFTWSAS GAIITESLAS ALPTIIVYVM DTARSTNPVT FMSNMLYACS
IMYKTKLPFI VLLNKIDIVD HSFITDWMTN FDSFQDALSM ETSYISNLTR SMSLVLDEFY
EHLKCVGVSS VTGLGMDNFM SAISTAIIEY NTEYKPELEK KKVLKTKNED DQKTLKSKSS
LESGFFTKPV PPNIPINYAT STVEESDEEN IDESEIREEH SFSHFLGSKI QSS
//
