ID T2MBC0_HYDVU Unreviewed; 1114 AA.
AC T2MBC0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Elongation factor Tu GTP-binding domain-containing protein 1 {ECO:0000313|EMBL:CDG69180.1};
GN Name=EFTUD1 {ECO:0000313|EMBL:CDG69180.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG69180.1};
RN [1] {ECO:0000313|EMBL:CDG69180.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG69180.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
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DR EMBL; HAAD01002948; CDG69180.1; -; mRNA.
DR AlphaFoldDB; T2MBC0; -.
DR EnsemblMetazoa; XM_012703298.1; XP_012558752.1; LOC100206687.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16268; EF2_II; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF3; ELONGATION FACTOR-LIKE GTPASE 1; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 2: Evidence at transcript level;
KW Elongation factor {ECO:0000313|EMBL:CDG69180.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:CDG69180.1}.
FT DOMAIN 24..268
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 1114 AA; 125595 MW; 0574FF37E605904A CRC64;
MVVSSSFYFL MELKNDKLKL DLSLQFIYRV DEFHVEPWKT TLADCLIASN GIISPKLAGK
LRYMDSREDE QQRGITMKSS AISLAYNTNK QNYLVNLIDS PGHVDFSSEV STAIRLCDGA
LIVIDVVEGV CPQTQAVLRQ AWLEGIKPCL VINKIDRLIT EVKLSPMEAY LQLQKVVEQV
NAVMGSLFST SVMEQSNVKI NTENSSTKVN ADGELSFDWS SGLEDADDEN LYFSPAAGNV
VFASAIDGWA FGIDTFAEIY SKKLGASYNV LSKTLWGDYY INIKAKKIAI GALSKGKKPL
FVQFILENLW NIYDAVILNR DTDRISKIVT NLNLKVSTRD SKTNNLQSHL QAILYQWLPL
SEAVLKMVSS SMPSPLDISE ERVKTLMCGR YKTIDIYSQD TQKLKDVIIK CGSEPESPVI
VFVSKMLSVL QSDLPKNRKK PLEELDVASR YEAAKKKLAD REMAAECAGD EFKESKVSVE
VEENDQCFIA FARVFSGVLK KGSKLFVLGP KYSPLIRAET LTDSPLKPVE EVVFGHKFSS
VYMAECTIGD LYLLMGKELN ILDAVPAGNI LGINGCADYI LKSATLSSTL ACPAFTPIPL
EAKPIVRVAV EPRQPSQLHR LVGGMKLLNQ ADPCVEVLVQ ETGEYVIVAA GEVHLQRCLD
DLTQRFAKIQ IKSSEPIVPF RETIVIPPKV DMVNEQISGT NKNAKHHTQR LPSYMLKEIQ
SFSDTIRKQE KSDINIKLQR YEEENSETFY MKDEIVALRK EAKKREKLGL IEAFTADKQY
CVCVHAKPLP LNVLKCLEQH NFLLKIIQRI YNEDDFQVAI NSLSIETKLQ IRQFYDQLRE
EFQRSGKLWK DIINRIWAIG PKGVNDNILI NNVNDYTRPS IWCGFIDELK NEGLHLREFD
NSVISGFQLA VQAGPICEEP MMGVAFFIED WKRLGNNENS YVENSLSYGP ISGQHISALK
AGCRRAFMAQ HLRLMAAMYS CDIQTTSDVL GKLYGVLGKR EGKILKENMK EGSDVFDIVA
QLPVAESFGF AEEIRKKTSG LASPQLIFSH WELLDIDPFW IPTTDEEYEL YGEKADSENQ
ALKYVNQIRK RKGLYVDEKT VEHAEKQRTL KKNK
//
