ID   T2MD90_HYDVU            Unreviewed;       277 AA.
AC   T2MD90;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=T-lymphoma invasion and metastasis-inducing protein 1 {ECO:0000313|EMBL:CDG70243.1};
GN   Name=TIAM1 {ECO:0000313|EMBL:CDG70243.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70243.1};
RN   [1] {ECO:0000313|EMBL:CDG70243.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG70243.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
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DR   EMBL; HAAD01004011; CDG70243.1; -; mRNA.
DR   AlphaFoldDB; T2MD90; -.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR   PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR   PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          18..211
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   277 AA;  32715 MW;  B6417468F3BD0EEA CRC64;
     MNGNLFENAP LSMKPSEKLR KSILELINTE ITYTKNLKIL QERYLIPLKE ENLLTSDEAD
     LLVKNIRDIY MFQKTFLEKL QEIKNNEKKM DAFEDVKQFQ NIIYLIGKLF LEFCDKFRLY
     STFCSCHSRA VKLLQVNTNE ALKAFLIARN PKQQHTASLE SYLITPIQRI LRYPLLIKTM
     MKYMLKDSEE YLCMNNALIS IEKVANYINE MQRINETFTP LFQDLAKRCP YVEILSTSSN
     IVKNDLEVRF STIISLNCLI LRDHAWSQNV QLRRKRC
//