ID T2MF94_HYDVU Unreviewed; 295 AA.
AC T2MF94;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Crk-like protein {ECO:0000313|EMBL:CDG70938.1, ECO:0000313|RefSeq:XP_012561143.1};
GN Name=CRKL {ECO:0000313|EMBL:CDG70938.1};
GN Synonyms=LOC100206935 {ECO:0000313|RefSeq:XP_012561143.1,
GN ECO:0000313|RefSeq:XP_012561144.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70938.1};
RN [1] {ECO:0000313|EMBL:CDG70938.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG70938.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
RN [2] {ECO:0000313|RefSeq:XP_012561143.1, ECO:0000313|RefSeq:XP_012561144.1}
RP IDENTIFICATION.
RC STRAIN=105 {ECO:0000313|RefSeq:XP_012561143.1,
RC ECO:0000313|RefSeq:XP_012561144.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; HAAD01004706; CDG70938.1; -; mRNA.
DR RefSeq; XP_012561143.1; XM_012705689.1.
DR RefSeq; XP_012561144.1; XM_012705690.1.
DR EnsemblMetazoa; XM_012705689.1; XP_012561143.1; LOC100206935.
DR EnsemblMetazoa; XM_012705690.1; XP_012561144.1; LOC100206935.
DR EnsemblMetazoa; XM_047268684.1; XP_047124640.1; LOC100206935.
DR EnsemblMetazoa; XM_047268685.1; XP_047124641.1; LOC100206935.
DR OMA; KMNVNGQ; -.
DR OrthoDB; 2900795at2759; -.
DR Proteomes; UP000694840; Unplaced.
DR CDD; cd11758; SH3_CRK_N; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR035457; CRK_SH3_N.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR19969:SF5; ADAPTER MOLECULE CRK; 1.
DR PANTHER; PTHR19969; SH2-SH3 ADAPTOR PROTEIN-RELATED; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50002; SH3; 2.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000694840};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 10..104
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 116..176
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 218..280
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 188..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 295 AA; 33157 MW; 31D1F6A236359FDE CRC64;
MADRLFMYSW YHGDITRPAC ESILMAQKPG LFLVRDSSTC KGGYVLSVSE NNKVSHYIIT
NKNSQYQIGD QTFNDLPEIV EFYKRHFLDT TTLVESAPRV TEPTPVTPAT SVTPPTQEIK
VKARYNFPGN DPEDLPFKKN DILTVLKKEE QQWWMARDSM GKEGMIPANY VELLPNRLSY
PLNNPPSTKP LRSSIHSGGG GYTSPPNVDS TTPASAASVP VIAEAMQDRT PTIYDPCELK
FQKGDRILVQ SMREDGTWEG QLMNGKRGIF PFTYVKIISN KPHDIAAWKA SFTQI
//
