ID   T2MFG2_HYDVU            Unreviewed;       847 AA.
AC   T2MFG2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   SubName: Full=Extracellular calcium-sensing receptor {ECO:0000313|EMBL:CDG70993.1};
DE   Flags: Fragment;
GN   Name=CASR {ECO:0000313|EMBL:CDG70993.1};
OS   Hydra vulgaris (Hydra) (Hydra attenuata).
OC   Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC   Aplanulata; Hydridae; Hydra.
OX   NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG70993.1};
RN   [1] {ECO:0000313|EMBL:CDG70993.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Whole animals {ECO:0000313|EMBL:CDG70993.1};
RX   PubMed=24065732; DOI=10.1093/gbe/evt142;
RA   Wenger Y., Galliot B.;
RT   "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT   bilaterian, euteleostome, and hominidae ancestors.";
RL   Genome Biol. Evol. 5:1949-1968(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; HAAD01004761; CDG70993.1; -; mRNA.
DR   AlphaFoldDB; T2MFG2; -.
DR   EnsemblMetazoa; XM_002162978.2; XP_002163014.1; LOC100201161.
DR   EnsemblMetazoa; XM_002162978.3; XP_002163014.1; LOC100201161.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   CDD; cd13953; 7tm_classC_mGluR-like; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR000337; GPCR_3.
DR   InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR   InterPro; IPR017978; GPCR_3_C.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   PANTHER; PTHR24060:SF162; G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR   Pfam; PF00003; 7tm_3; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   PRINTS; PR00248; GPCRMGR.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE   2: Evidence at transcript level;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:CDG70993.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        564..588
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        600..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        633..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        679..704
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        724..749
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        761..785
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        797..819
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          563..834
FT                   /note="G-protein coupled receptors family 3 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50259"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CDG70993.1"
SQ   SEQUENCE   847 AA;  96266 MW;  ED65495464A248AD CRC64;
     KLLVQNNLVK MFWNYNILIS LLFLITKSSA DWDWIGCYNK SKELYDTENT TVIIGGIFPI
     HFWDQENKKY VLNKPGLLWV EAMVFAINEI NNSPSFLQKT KVGYRILDSC NDIKKAMKSA
     LELTQGFPPD GKCLCNSSIS KVVAVVGDAA SATSAKVAAI LSSTVTTQIS YSATSTDFNA
     KQAYPSFLRT IPPDNMQALL IVDLLIHNKW TYVSLIACDD EYGRVGFSEL LQILKEVEVC
     IAVQEIYDVK SDVSDLLTIK VIEKIIQEEN ANVIVLWCQR PEAIRVLKKA ESLRLHNKTW
     IATETYGMSE NIYDIDPNVV RGMFGIVPFQ ALYEPFETML KSITPYTVNR NPWIQEYWRE
     KSCDKSSAIN CSNINLSELP KSKYAEVIHA VKSIAIGIQL YEKLNNTKPI QPKLLFPYVK
     NVSFTGLNNL TVSYDEQGNP VVASYSITNL KQIENRKLKW QVIGSWNDKS RGIILISDSQ
     IDYAGGSLKA PVSSCKEICK PGFFAFSFQS SCCWKCVKCT NDSIQPKYGQ SNCTPCTENK
     RSNINRTVCI QPERLYMKAN SKEGVLLITF STIGFIFVLF AIWTFYKYKD TFVVKASNRN
     LTLLQLVSIL FIILLPLVYI HKEIEVYKCG GQLFYFVCFN SIAISVNFTK ADRLLRIFKK
     SKSGRLTKFS ILKTNKVQFL TVGALTFIGI VLSLVSFFSF PVQVSYTQKT LENDKMLVVY
     YCGGYYDSIL FLMIGYVSLI ALVCGVYAFK ARNIPEIYNE ARLTSLAMFV FLLSWLIFIP
     LYLSANGEQQ KPEILCFVSF ISVICFFLIM YAPKLYIIFF KAKENVRGRI KVKVAEFTKI
     SNEFEKL
//