ID T2MGW7_HYDVU Unreviewed; 759 AA.
AC T2MGW7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Integrin beta {ECO:0000256|RuleBase:RU000633};
DE Flags: Fragment;
GN Name=ITGB2 {ECO:0000313|EMBL:CDG71513.1};
OS Hydra vulgaris (Hydra) (Hydra attenuata).
OC Eukaryota; Metazoa; Cnidaria; Hydrozoa; Hydroidolina; Anthoathecata;
OC Aplanulata; Hydridae; Hydra.
OX NCBI_TaxID=6087 {ECO:0000313|EMBL:CDG71513.1};
RN [1] {ECO:0000313|EMBL:CDG71513.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Whole animals {ECO:0000313|EMBL:CDG71513.1};
RX PubMed=24065732; DOI=10.1093/gbe/evt142;
RA Wenger Y., Galliot B.;
RT "Punctuated emergences of genetic and phenotypic innovations in eumetazoan,
RT bilaterian, euteleostome, and hominidae ancestors.";
RL Genome Biol. Evol. 5:1949-1968(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU000633}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU000633}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the integrin beta chain family.
CC {ECO:0000256|ARBA:ARBA00007449, ECO:0000256|RuleBase:RU000633}.
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DR EMBL; HAAD01005281; CDG71513.1; -; mRNA.
DR AlphaFoldDB; T2MGW7; -.
DR EnsemblMetazoa; XM_012706307.1; XP_012561761.1; LOC100213119.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.100; Cytochrome c1, transmembrane anchor, C-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR040622; I-EGF_1.
DR InterPro; IPR015812; Integrin_bsu.
DR InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR InterPro; IPR012896; Integrin_bsu_tail.
DR InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR InterPro; IPR002369; Integrin_bsu_VWA.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10082; INTEGRIN BETA SUBUNIT; 1.
DR PANTHER; PTHR10082:SF60; INTEGRIN BETA-PS; 1.
DR Pfam; PF18372; I-EGF_1; 1.
DR Pfam; PF08725; Integrin_b_cyt; 1.
DR Pfam; PF00362; Integrin_beta; 1.
DR PIRSF; PIRSF002512; Integrin_B; 1.
DR PRINTS; PR01186; INTEGRINB.
DR SMART; SM00187; INB; 1.
DR SMART; SM01241; Integrin_b_cyt; 1.
DR SMART; SM01242; Integrin_B_tail; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF69687; Integrin beta tail domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00243; INTEGRIN_BETA; 2.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU000633};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002512-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU000633};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000633};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 689..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..429
FT /note="Integrin beta subunit VWA"
FT /evidence="ECO:0000259|SMART:SM00187"
FT DOMAIN 607..684
FT /note="Integrin beta subunit tail"
FT /evidence="ECO:0000259|SMART:SM01242"
FT DOMAIN 712..758
FT /note="Integrin beta subunit cytoplasmic"
FT /evidence="ECO:0000259|SMART:SM01241"
FT DISULFID 14..24
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 17..49
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 27..37
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 164..176
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 224..267
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 373..381
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 401..644
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 427..431
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 451..489
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 456..465
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 495..500
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 497..532
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 502..517
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 519..524
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 540..545
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 542..575
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 547..556
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 581..586
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 583..627
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 588..597
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 600..603
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 607..616
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT DISULFID 613..679
FT /evidence="ECO:0000256|PIRSR:PIRSR002512-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CDG71513.1"
SQ SEQUENCE 759 AA; 84655 MW; 5AA6CDF7A34199BB CRC64;
FILEGKKCKE RSTCSECMLA SGECYWCADP GFPYDRCNLK PILQGDQNCK LISIEDNKVV
SEVNKEFSST IQVVPQEVSF KLRPFQSQQF KISVKPARDY PVQLYYLMDM SKSMEDDQEK
LKSLGKKIAE EINKITKNYQ LAFGSFVDKT VSPFTQVDII NHPCDLDEKF GKKGPCDPTF
GYRHNFNFDS NATKFEEAVA QQKISGNLDT PEGGFDGLMQ VSVCDTILGW KNMDQARRIV
IFVTDASPHI AGDGKIGGIT APNDGLCHLL DKDTYKIYDK SNEMDYPSIS QLKVKMKQNK
VVPILAVTSD VFPVYQKLAE QWKDTGAAIG KLEFDSSNIV DLIRDSYKKI ATTVRLIDDS
NRDRFTVRYK GSCSSPVDNE CQNVQIENQV DFTVTITALD CKSAKNDSFK ITIPGFGDVK
VNIEMICDCP CERDAGIPNA DICNKNGTSK CGICYCNPGR YGVNCDCDNK AQADTSLCKI
ANSTDDRVCS GFGICVCGQC ECIKRSAPDE RIYGKYCQCN NFGCDRYQGK ICGGPERGVC
DCQECKCKEA FQGANCGAIN CTIGAINCRK DNQVCSNNGV CACDTCVCSF GYKGKYCENC
VSCPGKCANV KDCVFCQAFK KGKDEVCSKC NLNIRIVNKT EEKCSYLDDD NCYVIFSFED
NEFAGTSNET ILVQKERKCI VIVPTDPPIL AIVLGTIGGI VLLGLILLLL WKLLITAYDN
YEYQRFERER MKSQWENAEN PIYKPSKQQF QNPTYAGNN
//
