ID   T2SE50_HELPX            Unreviewed;       245 AA.
AC   T2SE50;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=ComB8 competence protein {ECO:0000313|EMBL:EQD90996.1};
GN   ORFNames=L935_08260 {ECO:0000313|EMBL:EQD90996.1};
OS   Helicobacter pylori PZ5086.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1337395 {ECO:0000313|EMBL:EQD90996.1, ECO:0000313|Proteomes:UP000015855};
RN   [1] {ECO:0000313|EMBL:EQD90996.1, ECO:0000313|Proteomes:UP000015855}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PZ5086 {ECO:0000313|EMBL:EQD90996.1,
RC   ECO:0000313|Proteomes:UP000015855};
RX   PubMed=24051318;
RA   Sheh A., Piazuelo M.B., Wilson K.T., Correa P., Fox J.G.;
RT   "Draft Genome Sequences of Helicobacter pylori Strains Isolated from
RT   Regions of Low and High Gastric Cancer Risk in Colombia.";
RL   Genome Announc. 1:e00736-13(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQD90996.1}.
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DR   EMBL; ASYW01000210; EQD90996.1; -; Genomic_DNA.
DR   AlphaFoldDB; T2SE50; -.
DR   PATRIC; fig|1337395.3.peg.1286; -.
DR   Proteomes; UP000015855; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd16424; VirB8; 1.
DR   Gene3D; 3.10.450.230; VirB8 protein; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR007430; VirB8.
DR   Pfam; PF04335; VirB8; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        52..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..239
FT                   /note="Bacterial virulence protein VirB8"
FT                   /evidence="ECO:0000259|Pfam:PF04335"
SQ   SEQUENCE   245 AA;  28527 MW;  7CFA9CE7FBF2751B CRC64;
     MKEKPFNSEQ LIYLEELLSH QEKHLENKLS GFSVNDLDMQ SVFRLERNRL KIAYKLLGLM
     SFIALVLAIV LISILPLQKT EHHFVDFLNQ DKHYAIIQRA DKSISSNEAL ARSLIGAYVL
     NRESINRIDD KSRYELVRLQ SSSKVWQRFE DLIKTQNSIY AQSHLEREVH IVNIAIYQQD
     NNPIASVSIA AKLLNENKLV YEKRYKIVLS YLFDTPDFDY ASMPKNPTGF KITRYSITEI
     TNRGD
//