ID   T2T5U2_HELPX            Unreviewed;       833 AA.
AC   T2T5U2;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=L931_00800 {ECO:0000313|EMBL:EQD99935.1};
OS   Helicobacter pylori PZ5024.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1337391 {ECO:0000313|EMBL:EQD99935.1, ECO:0000313|Proteomes:UP000015645};
RN   [1] {ECO:0000313|EMBL:EQD99935.1, ECO:0000313|Proteomes:UP000015645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PZ5024 {ECO:0000313|EMBL:EQD99935.1,
RC   ECO:0000313|Proteomes:UP000015645};
RX   PubMed=24051318;
RA   Sheh A., Piazuelo M.B., Wilson K.T., Correa P., Fox J.G.;
RT   "Draft Genome Sequences of Helicobacter pylori Strains Isolated from
RT   Regions of Low and High Gastric Cancer Risk in Colombia.";
RL   Genome Announc. 1:e00736-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EQD99935.1}.
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DR   EMBL; ASYS01000007; EQD99935.1; -; Genomic_DNA.
DR   AlphaFoldDB; T2T5U2; -.
DR   PATRIC; fig|1337391.3.peg.24; -.
DR   Proteomes; UP000015645; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR   PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR   PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   Pfam; PF18135; Type_ISP_C; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:EQD99935.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EQD99935.1}.
FT   DOMAIN          292..491
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
FT   DOMAIN          718..825
FT                   /note="Type ISP restriction-modification enzyme LLaBIII C-
FT                   terminal specificity"
FT                   /evidence="ECO:0000259|Pfam:PF18135"
SQ   SEQUENCE   833 AA;  96855 MW;  8E110D9C8F8BB7E8 CRC64;
     MLKEYLEGIK DLTPESNELT HRLSLYTLLK GLKDNFNKEL KIEHEPNRDK QGGQPDFRIS
     YQGLNIGYIE NKRVGTDLNQ LLKSDQILKY LELNPNLMLT DYLNFVWVGK DEKNKPSIKR
     EISIASLDEL SKPLKPNPQT ERDLIELFRG FFNHEAAPIT NAKDFANALS APTRYLKDAL
     IQYQKDEQVS SIFKNFKEYL YEELSFEDFS DAFAQTLTYS LFIAKLNHPF EKIDLDNVRS
     SIPKNFAVIR EMADFLKKLD AIKEIQWLLN EILILINHVD MGSIIKDLND DKDHYLHFYE
     TFLSAYDPKL REKKGVYYTP DSVVKFIINA LDSLLKTHFK DAPLGLKSTL DNENIKLLDF
     ATGTGTFLLE AFRKALETRK TSDGGASTKE DKYQNLLKQF YGFEYLIAPY AIAHLNLSQA
     FKEEFKKPLK ENDALKIILT NTLIQPSEII AYRGLNPIFE KELSNAQEIK KNENILIITG
     NPPYSGASSN KGLFEWEVKA TYGIEPEFQT IEIEKNVKLA DKIQTLLKNV QKQKESGSKN
     SLKELKNLHS KYKLQKEKNP KWLLDDYVKF MRFAQNKIES LGHGLFGFIS NNAFLDNPTF
     RGLRRSLLEC YDELYILNLH GNARKKEKTP QGAKDENVFN IMQGVSINLF VKKAQATKPK
     IFYYDVYGER AEKYAFLAQH DLDSINWLEL APREPFYLLI PQETPLLEEY EQGFSVQEMF
     QISSVGIVTG RDHVVFHKDK ESLLKLLKDF STLEPSELRR KYDIGDDSRD WRLNNAIKEV
     KTNIKRLEEY IVSCQYRPFD YRWTYYTPNS RTFLAYPVYQ VFKHMLPPPP NKP
//