ID   T5A594_OPHSC            Unreviewed;       673 AA.
AC   T5A594;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Acyl transferase/acyl hydrolase/lysophospholipase {ECO:0000313|EMBL:EQK97575.1};
GN   ORFNames=OCS_06713 {ECO:0000313|EMBL:EQK97575.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQK97575.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQK97575.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQK97575.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR   EMBL; KE658174; EQK97575.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5A594; -.
DR   eggNOG; KOG2214; Eukaryota.
DR   HOGENOM; CLU_009031_1_0_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   CDD; cd07230; Pat_TGL4-5_like; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF10; TRIACYLGLYCEROL LIPASE 4-RELATED; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EQK97575.1};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW   Transferase {ECO:0000313|EMBL:EQK97575.1}.
FT   DOMAIN          77..274
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          455..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..509
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        609..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..673
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  74364 MW;  60306B060FB9750D CRC64;
     MHLIRTSLSR DLAGMGNVDL YRNSYVGTKK LIERYVDSAI QTIDAVVAQS ALDQGIDSRD
     LLEGMLFSRQ SFGRSALLLS GGGTFGMTHI GVLKALFEAR LLPRIISGSS AGSIVCAVMC
     TRTDDEIPAV IDEFPHGDLA VFEAADSNLG LLDHLRRLLT EGSWSNIDSL TRVMRGLTGD
     LTFQEAYNRT RRILNICVSP ASMYEVPRLL NYVTAPNVLI WSAVAASCSV PLFFSSSPLL
     VKDPVTGDHH HWNPTPQRYI DGSVDNDLPM TRLSEMFNVN HFIVSQVNPH VVPFLSKDDY
     LCPDAEPSRN RRRATELDWA NTLASLAKEE ALHRLQFMAD LGVFPNLMTK CRGVLSQKYS
     GDITILPEIT MHDLPRLMRN PTADFMLRSS VLGERATWPK LSRIRDRCAI ELALDGAVHR
     LRTRVVFSQS QRDLRGLSSL PRLRTRVVFS QSQRDLRGLS SGMAGPRPKA PLSVSGQPPL
     ADSLGIGLAS RRQRRRSGGS VQISSFGRTM MDLGITDDET AEEERSEMVW RRSQVDSPPA
     SRKPRLKRVS RSHVHVPLSR MSLPTSAHQS EFPRPPELDF SQPLPVSPRA ARHGVFDESK
     LSAWAQHAES PRGTATTPTD DMETSEQGHS SDADVEQGTD ESDSDPFEGE ARTVGAPKHQ
     GQTWSRGPIG SVC
//