ID T5A5F3_OPHSC Unreviewed; 1558 AA.
AC T5A5F3;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:EQL00680.1};
GN ORFNames=OCS_03612 {ECO:0000313|EMBL:EQL00680.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL00680.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL00680.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL00680.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
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DR EMBL; KE652726; EQL00680.1; -; Genomic_DNA.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_4_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF54; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1467..1546
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1558 AA; 169485 MW; 238F0B5CEAFCE90A CRC64;
MFSSVTGKRV AAPLPLEYWR QNLESPVLFS QAAQSLLRSV PGIRCVVEVG PHSALGGPVK
EIRAALGRGE EQLQYLSALK RNTDGVETVL NLVGALFLSG HSVALDRVNA DELVEPETGA
VRLQRGPFLT DFPRYQWVYD DVYWSESRLS SDVRFRKHAR HDLLGSLLPG SSKASPSWRN
VLKLDQLPWL RDHKVGGDIV FPAAGYISLA MTAAAQASGL HRDSPTYTLG NVKIKSAMVL
KEGVGTESLL DLYSLNSDGT EFDFTVSSVC CGEWAIHASG NVRISKPSAL PAIFTSKARA
TCTGVNQETQ DRRWYQKMRD VGLAYGPAFK TLSGIRSTAD RFEALADVDI EAPGGSMVQE
SEYAVHPTVL DACLQLSIIA AHRGEPNNLV KSYLPVAVEH MTVATAPSTG RAVVRGLGRP
NGLRSIKTAV ELTGADGDVL VQARLSFLSL ESSINSQSEA KIPQPYSRLV WKPDISRLSG
DQLRSVLSDG QSCPSACQVG SHAKLEKLAD LIAHQDPRLN ILELNGGEGP SRRLLTALRG
HHAIPNYVKY RFADESAEFL ASVQEQYRDF HKLEFARLDM EQDPSPQGFD EASYDIIFAP
NVVHAKRSLA GTLKHCRKLL KPGGRLIMIE TVTASVMLSK AEWNQRLVDA GFSGADVMFD
YPEPGSCSAL IVTRPDEQGS TIKGTGEDED EVVLLYRHEP HALLVELEKL YHERSVPSRR
MAFTDLPQSG IQKARTVMLA ELEGPLLSRM SEAEMAAMRA YTQLASTAVW VTNGDVLAGR
EPEKTLVFGI SKSIMTEQPS FHLASIDIDP DAALASSARL VVDMEAEFRR NPHDMNTELV
EKGGVVYSSR YMADDDGNAA FARSWMPPTE RLPIRGNLSM GFDRVGRLDS FHFEDVSGAE
TALGETDVLV EARAFAFDQT GLAVAKGQKS HPFFTLEAGG IVAKTGSQVH GIRPGDAVVC
LKPNTFETTL AVHQDFVSRL DGADGIDDIV SQLLPYTFAV HTLAHVCRPA RHDAVLVDVS
WPALACALVQ MALRAGCSVY ATYFSQEMKG LLEPLQGVHL MDSRAGLELG IPSHVAFRVM
LTNGSVDLGA VLQRFVDRGA HLALLPGRAS TYLAAIYASL VSKGLTVSYL DPWDMTSCNQ
INVSSAMRDA VHLLQHGLVA RIPSDSFDLS RFSDAAAAVN ASPVRAVLTC DPEATLVPIK
QTPEPLTFDG NGTYLLIGCL GGLGRSLTIW MISRGARNFI FLSRSGADKP EAAALMADLR
GMGQSQTCKL SLQVARGDVS RREDVAAAIS LASTPIRGVI QAAMVLHELI FNTMSLQQWN
QVIQPKVLGT MHLDELLAYH DLDFFVMTSS VLGAIGAATQ SNYSAANAYL DAMARHRHSR
GLQATSLALG MVLEVGHVEE HPEVEVALKR NGMYGIGVTT MLVLGPAMSL LSVSMVYSNY
DHLCLEVKPC SQDRCGRGAA AETGGIEAVK AVVQQLLMGH LSKLVLLPVQ KMRPQTPLSV
YGMDSMISAE LRNWTWKEFK ADVPFMSLLD QSLTFERLAE QVVGVMDREL RDSLNDST
//
