ID T5AFP5_OPHSC Unreviewed; 1109 AA.
AC T5AFP5;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=OCS_03053 {ECO:0000313|EMBL:EQL01236.1};
OS Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS caterpillar fungus) (Hirsutella sinensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL01236.1, ECO:0000313|Proteomes:UP000019374};
RN [1] {ECO:0000313|EMBL:EQL01236.1, ECO:0000313|Proteomes:UP000019374}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC TISSUE=Fruit-body {ECO:0000313|EMBL:EQL01236.1};
RX DOI=10.1007/s11434-013-5929-5;
RA Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA Liu X., Wang C.;
RT "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT fungus.";
RL Chin. Sci. Bull. 58:2846-2854(2013).
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DR EMBL; KE652541; EQL01236.1; -; Genomic_DNA.
DR AlphaFoldDB; T5AFP5; -.
DR eggNOG; KOG0941; Eukaryota.
DR HOGENOM; CLU_002173_5_1_1; -.
DR Proteomes; UP000019374; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000019374};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 762..1109
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 478..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 406..433
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 87..106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..308
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1077
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1109 AA; 123951 MW; C8C6A33BE70948B7 CRC64;
MSNPFPSLFN TKKKRRDSAG RGFEPECDPS PLVGHSPRRH TRGGMAGSKD FATGHCMTCA
SLVKWPKELK VFKCTICSTI NHLVPVESES HRGDRPSSRR RDASRDPGAS GCQGQSISIQ
HSKWLTRQCL HSFLARRLCA PPQSSFEARQ DHSACPPLSG PLRPAADARG YGRSPWDEDG
RRTSDDPPAY EPRYVFDQEP TLRLHPPRPG NVTSRSHSSP HSERPWLRPP ASRIQTSPPR
RDPSASRQDE YKRIFKPLAD YIVTCFGSVT CVNSSFMTSS RPTTRHAGDL PVRRKPVPSR
EPPRRRQAAE TSRAGPQADG FLSELDPKML LLGDFAENGT WWTGGQEGAS TATSAYRIDG
PSRACTSPKS PHLNWQELSD WYSSVINAAE GWFEVYEEVS RDPDFLQPAE KDLETLEGEL
LRAQTQLQRV LLKATEQLLK RPGRPLAAPV DLRFLLVLLE NPLLHPDLAT FEGLIQPQSG
SAPKWSDSSS EKSSRPRTGL LSGQHSGIIK RIVGLLSNSS TECHNHLISW LAEFPTARFV
RAKDIVSGFL TYRLLRQSVK TRPARVDITA GLIPEMQVGR SAGAYLHDEI GSGSSKKQKE
SDKKIVYADD WQIKAAARVL ALFFAANNLQ SSRVGDGVLP NTGEIQIAAV RDGVHASGQL
LPTSDFYNLV IDNADLVGDF ESWESKRAKF SFCQYPFLLS IWAKTKILEY DARRQMQNKA
RDAFFDSIMT RRNIKQYLSL DVRRECLVDD SLKAVGEVIG SGSEDVKKAL RITFRGEEGI
DGGGLRKEWF LLLVREVFNP DHGMFLYDED SRYCYFNPNS FETSDQFFLV GVVMGLAIYN
STILDVALPP FTFRKLLASA PCHGQGPSAH PRPTMKYTLD DLAEYKPRLA RGLRQLLDYD
GDVEHTFSLD FVVDIEKYGT TVQVPLCPGG GRKPVTNGNR REYVDLYLRH VLDAAVARQY
EPFKRGFYTV CGGNAFSLFR PEEIELLIRG SDAPLDIEAL RAVAEYDNWG SPTPDGTEAV
VGWFWETFQS APPADQRSML LFVTGSDRIP AMGASMLTIK ISCLGEDCGR FPIARTCFNL
LSLWRYGTKD RLEAMLWRAV RESEGFGLK
//
