ID   T5AN35_OPHSC            Unreviewed;       903 AA.
AC   T5AN35;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=GTPase FZO1 {ECO:0000313|EMBL:EQL03137.1};
GN   ORFNames=OCS_01156 {ECO:0000313|EMBL:EQL03137.1};
OS   Ophiocordyceps sinensis (strain Co18 / CGMCC 3.14243) (Yarsagumba
OS   caterpillar fungus) (Hirsutella sinensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Ophiocordyceps.
OX   NCBI_TaxID=911162 {ECO:0000313|EMBL:EQL03137.1, ECO:0000313|Proteomes:UP000019374};
RN   [1] {ECO:0000313|EMBL:EQL03137.1, ECO:0000313|Proteomes:UP000019374}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Co18 / CGMCC 3.14243 {ECO:0000313|Proteomes:UP000019374};
RC   TISSUE=Fruit-body {ECO:0000313|EMBL:EQL03137.1};
RX   DOI=10.1007/s11434-013-5929-5;
RA   Hu X., Zhang Y., Xiao G., Zheng P., Xia Y., Zhang X., St Leger R.J.,
RA   Liu X., Wang C.;
RT   "Genome survey uncovers the secrets of sex and lifestyle in caterpillar
RT   fungus.";
RL   Chin. Sci. Bull. 58:2846-2854(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001270};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000256|ARBA:ARBA00004374}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004374}.
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DR   EMBL; KE652232; EQL03137.1; -; Genomic_DNA.
DR   AlphaFoldDB; T5AN35; -.
DR   eggNOG; KOG0448; Eukaryota.
DR   HOGENOM; CLU_011752_0_0_1; -.
DR   Proteomes; UP000019374; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007005; P:mitochondrion organization; IEA:UniProt.
DR   CDD; cd00882; Ras_like_GTPase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR030381; G_DYNAMIN_dom.
DR   InterPro; IPR027094; Mitofusin_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10465; TRANSMEMBRANE GTPASE FZO1; 1.
DR   PANTHER; PTHR10465:SF0; TRANSMEMBRANE GTPASE MARF-RELATED; 1.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51718; G_DYNAMIN_2; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019374}.
FT   DOMAIN          260..568
FT                   /note="Dynamin-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51718"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          475..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..524
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   903 AA;  98921 MW;  9C616E3254889E6D CRC64;
     MSQDYFNGKG KAPARREPDS DSDARKNAAP GLNRASYMTV GTGSISEHGA HLRNMMDVDS
     GYGDSISSED YLGARSEPAW DASLHRDRPQ SGVLHQMWYN AQRSKLARSI NKVLEILESF
     REINTSWPAH YPSVQRVAWA TPSERSASRP GFAHMHSMVD MSTPSSTADN PPALRRSVTM
     VEDPSAESSR AAQSRAVSEP RLVSAQIAQE FSILKLDLKL GSLHQAELVH SLEKGSIASL
     LDGKINSSIN HLLSLRGRIE DTSSKVLITG DLNAGKSTFC NALLRRKVLP EDQQPCTAIF
     CEVLDARANA GIEEVHAVHK DANYNRNDES TFDVFPLKHL EKIVIDHETY TQCKVYVKDI
     RTIDQSLLNN GVVDIALIDA PGLNSDTTKT TAIFARQEEI DVVVFVVSAA NHFTQSATEF
     IRAPAAEKAY LFIVVNGYDT IKAKERCQKL ILDQVSGLSP RTHKESSELV HFVSSNAIPA
     GPSPPGGPGG SGSGSSSGGG GGDDPSDDTD GTSGKGKGTD MDKVRDFEAL EQSLRRFVLE
     KRARSKLAPA RTYLLNILND VNMLATVNRS MAQSELDRVI EELKVLEPQL ETSRQAQSEV
     GDQVNQNIED TCQDVYGHSR AELSAAITYA GKTNYDVPYP GFLGAFQYAD DLKEAMLSHI
     ADAVSDCEEY ARRKTVQSVN VVKQLGLLHI GDEFQTLQFR SDVMFRRKRH ALARQVDIST
     DLFDFVDWST LLQHQEKLAG TGMALTVAGA VVPRMIGMST WLDQAVAAAR LLGNRNLRQL
     IIPGVIVAAV AASAYVLQQI PNSLPQRLAM KISVHLAEID YVHSNSTRIS SSVRKILRIP
     ADNLRSALEQ SVKDLGSRLD ETAKVKGESD KAAEYFRTLV SESEMQRSMV EDVDLDAPPP
     GLH
//