ID T5CEK0_HELPX Unreviewed; 775 AA.
AC T5CEK0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Penta-phosphate guanosine-3'-pyrophosphohydrolase {ECO:0000313|EMBL:EQL49979.1};
GN ORFNames=N403_07160 {ECO:0000313|EMBL:EQL49979.1};
OS Helicobacter pylori FD430.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191280 {ECO:0000313|EMBL:EQL49979.1, ECO:0000313|Proteomes:UP000015937};
RN [1] {ECO:0000313|EMBL:EQL49979.1, ECO:0000313|Proteomes:UP000015937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD430 {ECO:0000313|EMBL:EQL49979.1,
RC ECO:0000313|Proteomes:UP000015937};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL49979.1, ECO:0000313|Proteomes:UP000015937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD430 {ECO:0000313|EMBL:EQL49979.1,
RC ECO:0000313|Proteomes:UP000015937};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL49979.1}.
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DR EMBL; AKHN02000115; EQL49979.1; -; Genomic_DNA.
DR RefSeq; WP_001002240.1; NZ_AKHN02000115.1.
DR AlphaFoldDB; T5CEK0; -.
DR PATRIC; fig|1191280.5.peg.206; -.
DR Proteomes; UP000015937; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EQL49979.1}.
FT DOMAIN 60..180
FT /note="HD/PDEase"
FT /evidence="ECO:0000259|SMART:SM00471"
FT DOMAIN 265..375
FT /note="RelA/SpoT"
FT /evidence="ECO:0000259|SMART:SM00954"
SQ SEQUENCE 775 AA; 89129 MW; 01DD78D9CB11815B CRC64;
MNEIDKSVDI GFLRILDVIK KVTTPKGGIE ILRTLIDFTP KIENALNLAT KSHKGQYRKS
GEPYIVHPIC VASLVAFCGG DEAMVCAALL HDVVEDTPCK IETIEQEFGQ DVANLVDALT
KITEIRKEEL GVSPQDPRMV VSALTFRKIL ISAIQDPRAL VVKISDRLHN MLTLDALPHD
KQVRISKETL AVYAPIASRL GMSSIKNELE DKSFYYIYPE EYKNIKEYLH KNKQSLLLKL
NAFASKLEKK LFDSGFSHSD FKLVTRVKRP YSIYLKMQRK GAVNIDEILD LLAIRILLKN
PIDCYKVLGI IHLNFKPIVS RFKDYIALPK ENGYKTIHTT IFDESSVYEV QIRTFDMHMG
AEYGNSAHWK YKAGGVDNED HHEGMRWLQN FKYHDSDLKN DPKEFYELAK NDLYREDIVV
FSPHGDTYTL PVGAIALDFA YMVHSDLGDK ATDAYINSKK ALLNQELRSG DVVKIVKGDK
IIPRFIWMDQ LKTSKAKNHL RIQRRNRLKE IDTKSMINIL ATFFGRSVFE DVDLKDYKNF
EEKLTDCGVE TTLTEAMKSF ENLAKLTEEI ENKVFSLKED AILEYQEMSL WTRGLRYLGF
KTNVLNFLAP NRQWQCKELE HFSVCSSNAL EIKQVLLNDC CYPKYGDEII AIVTDLKDPK
AVAHHKFCKK AMAEVDAKVP MVYIEWHKRD RTIYKMMFYL GEKKSVLAGL LTFLNRNECN
IVGVSYLGYK DKYSSHCEVS FEIATDKADW IRALINRKYQ DRIVELSSLD DAYES
//
