ID T5CV17_HELPX Unreviewed; 983 AA.
AC T5CV17;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE SubName: Full=Transporter {ECO:0000313|EMBL:EQL60330.1};
GN ORFNames=N405_04365 {ECO:0000313|EMBL:EQL60330.1};
OS Helicobacter pylori FD568.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191282 {ECO:0000313|EMBL:EQL60330.1, ECO:0000313|Proteomes:UP000015965};
RN [1] {ECO:0000313|EMBL:EQL60330.1, ECO:0000313|Proteomes:UP000015965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD568 {ECO:0000313|EMBL:EQL60330.1,
RC ECO:0000313|Proteomes:UP000015965};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL60330.1, ECO:0000313|Proteomes:UP000015965}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD568 {ECO:0000313|EMBL:EQL60330.1,
RC ECO:0000313|Proteomes:UP000015965};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- SIMILARITY: Belongs to the TrbE/VirB4 family.
CC {ECO:0000256|ARBA:ARBA00006512}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL60330.1}.
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DR EMBL; AKHQ02000056; EQL60330.1; -; Genomic_DNA.
DR RefSeq; WP_000495964.1; NZ_AKHQ02000056.1.
DR AlphaFoldDB; T5CV17; -.
DR PATRIC; fig|1191282.4.peg.908; -.
DR Proteomes; UP000015965; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 1.10.8.730; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR004346; CagE_TrbE_VirB.
DR InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR043964; P-loop_TraG.
DR NCBIfam; TIGR00929; VirB4_CagE; 1.
DR PANTHER; PTHR30121:SF6; TYPE IV SECRETION SYSTEM PROTEIN CAGE; 1.
DR PANTHER; PTHR30121; UNCHARACTERIZED PROTEIN YJGR-RELATED; 1.
DR Pfam; PF03135; CagE_TrbE_VirB; 1.
DR Pfam; PF19044; P-loop_TraG; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 326..531
FT /note="CagE TrbE VirB component of type IV transporter
FT system central"
FT /evidence="ECO:0000259|Pfam:PF03135"
FT DOMAIN 579..912
FT /note="TraG P-loop"
FT /evidence="ECO:0000259|Pfam:PF19044"
SQ SEQUENCE 983 AA; 111952 MW; D89F7BC56197DBB6 CRC64;
MFVASKQADE QKKLIIEQEV QKRQFQKIEE LKADMQKGVN PFFKVLFDGG NRLFGFPETF
IYSSIFILFV TIVLSVILFQ AYEPVLIVAI VIVLVALGFK KDYRLYQRME RAMKFKKPFL
FKGVKNKAFM SIFSMKPSKE MANDIHLNPN REDRLVSAAN SYLANNYECF LDDGVILTNN
YSLLGTIKLG GIDFLTTSKK DLIELHASIY SVFRNFVTPE FKFYFHTVKK KIVIDETNRD
YSLAFSNDFM RAYNEKQKRE SFYDISFFLT IEQDLLDTLN EPVMNKKHFA DNNFEEFQRI
IRAKLENFKD RIELIEELLS KYHPTRLKEY TKDGVIYSKQ CEFYNFLVGM NEAPFICNRK
DLYLKEKMHG GVKEVYFANK HGKILNDDLS EKYFSAIEIS EYAPKSQSDL FDKINALDSE
FIFMHAYSPK NSQVLKDKLA FTSRRIIISG GSKEQGMTLG CLSELVGNGD ITLGSYGNSL
VLFADSFEKM KQSVKECVSS LNAKGFLANA ATFSMENYFF AKHCSFITLP FIFDVTSNNF
ADFIAMRAMS FDGNQENNAW GNSVMTLKSE INSPFYLNFH MPTDFGSASA GHTLILGSTG
SGKTVFMSMT LNAMGQFAHN FPANVSKDRQ KLTMVYMDKD YGAYGNIVAM GGEYVKIELG
TDTGLNPFAW AACVQKSNAT MEQKQTAISV VKELVKNLAT KSDEKDENGN STTFSLADSN
TLAAAVTNLI TGDMNLDYPI TQLINAFGKD HNDPNGLVAR LAPFCKSTNG EFQWLFDNKA
TDRLDFSKTI IGVDGSSFLD NNDVSPFICF YLFARIQEAM DGRRFVLDID EAWKYLGDPK
VAYFVRDMLK TARKRNAIVR LATQSITDLL ACPIADTIRE QCPTKIFLRN DGGNLSDYQR
LANVTEKEFE IITKGLDRKI LYKQDGSPSV IASFNLRGIP KEYLKILSTD TVFVKEIDKI
IQNHSIIDKY QALRQMYQQI KEY
//
