ID T5DDW2_HELPX Unreviewed; 285 AA.
AC T5DDW2;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=3-hydroxyacid dehydrogenase {ECO:0000313|EMBL:EQL73143.1};
GN ORFNames=N409_05495 {ECO:0000313|EMBL:EQL73143.1};
OS Helicobacter pylori FD719.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1191286 {ECO:0000313|EMBL:EQL73143.1, ECO:0000313|Proteomes:UP000015963};
RN [1] {ECO:0000313|EMBL:EQL73143.1, ECO:0000313|Proteomes:UP000015963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD719 {ECO:0000313|EMBL:EQL73143.1,
RC ECO:0000313|Proteomes:UP000015963};
RX PubMed=23012278; DOI=10.1128/JB.01278-12;
RA Gunaletchumy S.P., Teh X., Khosravi Y., Ramli N.S., Chua E.G., Kavitha T.,
RA Mason J.N., Lee H.T., Alias H., Zaidan N.Z., Yassin N.B., Tay L.C.,
RA Rudd S., Mitchell H.M., Kaakoush N.O., Loke M.F., Goh K.L., Vadivelu J.;
RT "Draft genome sequences of Helicobacter pylori isolates from Malaysia,
RT cultured from patients with functional dyspepsia and gastric cancer.";
RL J. Bacteriol. 194:5695-5696(2012).
RN [2] {ECO:0000313|EMBL:EQL73143.1, ECO:0000313|Proteomes:UP000015963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FD719 {ECO:0000313|EMBL:EQL73143.1,
RC ECO:0000313|Proteomes:UP000015963};
RX PubMed=24051312;
RA Rehvathy V., Tan M.H., Gunaletchumy S.P., Teh X., Wang S., Baybayan P.,
RA Singh S., Ashby M., Kaakoush N.O., Mitchell H.M., Croft L.J., Goh K.L.,
RA Loke M.F., Vadivelu J.;
RT "Multiple genome sequences of Helicobacter pylori strains of diverse
RT disease and antibiotic resistance backgrounds from malaysia.";
RL Genome Announc. 1:E00687-E00713(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EQL73143.1}.
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DR EMBL; AKHU02000035; EQL73143.1; -; Genomic_DNA.
DR RefSeq; WP_020981603.1; NZ_AKHU02000035.1.
DR AlphaFoldDB; T5DDW2; -.
DR PATRIC; fig|1191286.4.peg.788; -.
DR Proteomes; UP000015963; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 161..280
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 167
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 285 AA; 30573 MW; 87FF442665507BEC CRC64;
MKIGWIGLGA MGTPMATRLC DAGLKVSVYN RTESKATPLK EKGVAFYTNP IDLAAKVDLV
FTMLSDKTAI DAVLAPKFWE QMSEKIVVNM STIAPLESLA LEKTAQKHQV TYLEAPVSGS
VGAVKAGALL ILAAGNKEVI TQLKPVLAHL GSQTFYLGKI GQGAGAKLSI NSLLAQMGVA
YSEALLLAKH LGVDAESFLQ IIGQSGMNSP LFQAKKGMWL QDSYPAAFSL KLMLKDIRLA
NNEAGEAIQL PFLSKAQELY SQAEKSGLGE LDMVAVYHYL EKGEH
//
