ID TA2R7_MOUSE Reviewed; 312 AA.
AC P59530; Q0VE81; Q7M726;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-APR-2003, sequence version 1.
DT 24-JAN-2024, entry version 130.
DE RecName: Full=Taste receptor type 2 member 7;
DE Short=T2R7;
DE AltName: Full=STC7-4;
DE AltName: Full=T2R30;
DE AltName: Full=T2R6;
DE AltName: Full=mT2R42;
GN Name=Tas2r7; Synonyms=Tas2r130, Tas2r6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12920489; DOI=10.1007/s00251-003-0591-8;
RA Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N.,
RA Stoll J., Yokoyama W.M., Brown M.G.;
RT "Molecular genetic characterization of the distal NKC recombination hotspot
RT and putative murine CMV resistance control locus.";
RL Immunogenetics 55:370-378(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zuker C.S., Adler J.E., Ryba N., Mueller K., Hoon M.;
RT "T2r taste receptor family.";
RL Patent number WO0118050, 15-MAR-2001.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [6]
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
RN [7]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [8]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [9]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in 15% taste bud cells in circumvallate and foliate
CC papillae but only in 2% in fungiform papillae. Expressed in gastric and
CC duodenal tissues.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF462604; AAO14564.1; -; Genomic_DNA.
DR EMBL; AX097857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC140204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119329; AAI19330.1; -; mRNA.
DR EMBL; AF412303; AAL85200.1; -; mRNA.
DR EMBL; BK001071; DAA01210.1; -; Genomic_DNA.
DR CCDS; CCDS20608.1; -.
DR RefSeq; NP_954607.1; NM_199156.1.
DR AlphaFoldDB; P59530; -.
DR SMR; P59530; -.
DR STRING; 10090.ENSMUSP00000063954; -.
DR GlyCosmos; P59530; 2 sites, No reported glycans.
DR GlyGen; P59530; 2 sites.
DR PhosphoSitePlus; P59530; -.
DR PaxDb; 10090-ENSMUSP00000063954; -.
DR Antibodypedia; 23392; 163 antibodies from 22 providers.
DR DNASU; 387355; -.
DR Ensembl; ENSMUST00000067597.5; ENSMUSP00000063954.5; ENSMUSG00000054497.6.
DR GeneID; 387355; -.
DR KEGG; mmu:387355; -.
DR UCSC; uc009eiv.1; mouse.
DR AGR; MGI:2681278; -.
DR CTD; 387355; -.
DR MGI; MGI:2681278; Tas2r130.
DR VEuPathDB; HostDB:ENSMUSG00000054497; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; P59530; -.
DR OMA; WRIDRVI; -.
DR OrthoDB; 5306466at2759; -.
DR PhylomeDB; P59530; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387355; 3 hits in 76 CRISPR screens.
DR PRO; PR:P59530; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P59530; Protein.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR CDD; cd15023; 7tm_TAS2R7-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF58; TASTE RECEPTOR TYPE 2 MEMBER 7; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..312
FT /note="Taste receptor type 2 member 7"
FT /id="PRO_0000082217"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..101
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 66
FT /note="C -> G (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 84..85
FT /note="TV -> II (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 107..108
FT /note="YL -> HF (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 138..140
FT /note="VII -> LIL (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="S -> T (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="V -> L (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="H -> Y (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="I -> M (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 218
FT /note="S -> N (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 223
FT /note="K -> N (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="M -> T (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="A -> V (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
FT CONFLICT 245
FT /note="V -> I (in Ref. 5; AAL85200)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 312 AA; 35510 MW; 73EBE2CA794AAF22 CRC64;
MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS VAMSRICLQC
IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA TCLSIFYLFK IANFFHPLFL
WIKWRIDKLI LRTLLACVII SLCFSLPVTE NLSDDFRRCV KTKERINSTL RCKVNKAGHA
SVKVNLNLVM LFPFSVSLVS FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF
LALFVVYCLA FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL
CRVKTMLKGK KY
//
