ID TBL3_RAT Reviewed; 800 AA.
AC Q5U2W5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE RecName: Full=Transducin beta-like protein 3;
GN Name=Tbl3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the small subunit (SSU) processome, first precursor
CC of the small eukaryotic ribosomal subunit. During the assembly of the
CC SSU processome in the nucleolus, many ribosome biogenesis factors, an
CC RNA chaperone and ribosomal proteins associate with the nascent pre-
CC rRNA and work in concert to generate RNA folding, modifications,
CC rearrangements and cleavage as well as targeted degradation of pre-
CC ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:Q12788}.
CC -!- SUBUNIT: Part of the small subunit (SSU) processome, composed of more
CC than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
CC {ECO:0000250|UniProtKB:Q12788}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:Q12788}.
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DR EMBL; BC085837; AAH85837.1; -; mRNA.
DR RefSeq; NP_001008278.1; NM_001008277.1.
DR AlphaFoldDB; Q5U2W5; -.
DR SMR; Q5U2W5; -.
DR STRING; 10116.ENSRNOP00000018405; -.
DR iPTMnet; Q5U2W5; -.
DR PhosphoSitePlus; Q5U2W5; -.
DR PaxDb; 10116-ENSRNOP00000018405; -.
DR Ensembl; ENSRNOT00000018405.6; ENSRNOP00000018405.4; ENSRNOG00000013429.6.
DR Ensembl; ENSRNOT00055048737; ENSRNOP00055040051; ENSRNOG00055028159.
DR Ensembl; ENSRNOT00060018033; ENSRNOP00060014038; ENSRNOG00060010647.
DR Ensembl; ENSRNOT00065014825; ENSRNOP00065011083; ENSRNOG00065009275.
DR GeneID; 287120; -.
DR KEGG; rno:287120; -.
DR UCSC; RGD:1305142; rat.
DR AGR; RGD:1305142; -.
DR CTD; 10607; -.
DR RGD; 1305142; Tbl3.
DR eggNOG; KOG0319; Eukaryota.
DR GeneTree; ENSGT00940000157651; -.
DR HOGENOM; CLU_009276_1_0_1; -.
DR InParanoid; Q5U2W5; -.
DR OMA; PYVQRHF; -.
DR OrthoDB; 35744at2759; -.
DR PhylomeDB; Q5U2W5; -.
DR TreeFam; TF314872; -.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q5U2W5; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000013429; Expressed in pancreas and 20 other cell types or tissues.
DR Genevisible; Q5U2W5; RN.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; ISS:UniProtKB.
DR GO; GO:0034511; F:U3 snoRNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISS:UniProtKB.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR013934; Utp13_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19854; TRANSDUCIN BETA-LIKE 3; 1.
DR PANTHER; PTHR19854:SF15; TRANSDUCIN BETA-LIKE PROTEIN 3; 1.
DR Pfam; PF08625; Utp13; 1.
DR Pfam; PF00400; WD40; 9.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 9.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Isopeptide bond; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT CHAIN 2..800
FT /note="Transducin beta-like protein 3"
FT /id="PRO_0000362981"
FT REPEAT 64..105
FT /note="WD 1"
FT REPEAT 107..146
FT /note="WD 2"
FT REPEAT 149..190
FT /note="WD 3"
FT REPEAT 193..232
FT /note="WD 4"
FT REPEAT 245..284
FT /note="WD 5"
FT REPEAT 290..329
FT /note="WD 6"
FT REPEAT 332..372
FT /note="WD 7"
FT REPEAT 374..413
FT /note="WD 8"
FT REPEAT 419..459
FT /note="WD 9"
FT REPEAT 477..516
FT /note="WD 10"
FT REPEAT 519..560
FT /note="WD 11"
FT REPEAT 562..602
FT /note="WD 12"
FT REPEAT 604..642
FT /note="WD 13"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
FT CROSSLNK 407
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q12788"
SQ SEQUENCE 800 AA; 88372 MW; 3F1B4D1B3925D8C7 CRC64;
MAETAAGLCR FKANYAVERK IEPFYKGGKA QLDQTGRHLF CVCGTKVNIL DVASGDLIRS
LEQEDQEDIT AFDLSPDDEV LVTASRALLL AQWAWREGTV ARLWKAIHTA PVASMAFDAT
STLLATGGCD GAVRVWDIVQ HYGTHHFRGS PGVVHLVAFH PDPTRLLLFS SAVDTSIRVW
SLQDRSCLAV LTAHYSAVTS LSFSEDGHTM LSSGRDKICI VWDLRSYETS RTVPVFESVE
ASVLLPEEPA LALGVKNSGL HFLTAGDQGI LRVWEAASGQ CVYTQPQMSG LRQELTHCTL
ARAAGLLLTV TADHNLLLYE ARSLQLQKQF AGYSEEVLDV RFLGPNDSHI IVASNSPCLK
VFELQTLACQ ILHGHTDIVL ALDVFRKGWL FASCAKDQSI RIWRMNKAGQ VACVAQGSGH
THSVGTICCS RLKESFLVTG SQDCTVKLWP LPEALPSKNT ASDGDLIPLQ AQSTQRCHDK
DINSLAVSPN DKLLATGSQD RTAKLWALPQ CQLLGVFSGH RRGLWNVQFS PTDQVLATAS
ADGTIKLWAL QDFSCLKTFE GHDASVLKVA FVSRGAQLLS SGSDGLLKLW TIKSNECVRT
LDAHEDKVWG LHCSRLDDHA ITGGSDSRII LWKDVTEAEQ AEEQAKREEQ VIKQQELDNL
LHEKRYLRAL GLAISLDRPH TVLTVIQAIR RDPEACEKLE ATVLRLRRDQ KEALLRFCIT
WNTNSRHCHE AQAVLGVLLR HEAPEELLAY DGVRGALEAL LPYTERHFQR LSRTLQAATF
LDFLWHNMKL SPLPAAPPAL
//
