ID TFX_METTH Reviewed; 138 AA.
AC O27001;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2003, sequence version 3.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=DNA-binding protein Tfx;
GN Name=tfx; OrderedLocusNames=MTH_916;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Transcriptional activator of the fmdECB operon.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Tfx family. {ECO:0000255|HAMAP-
CC Rule:MF_00620}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB85414.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE000666; AAB85414.1; ALT_INIT; Genomic_DNA.
DR PIR; F69222; F69222.
DR PDB; 1NR3; NMR; -; A=17-138.
DR PDBsum; 1NR3; -.
DR AlphaFoldDB; O27001; -.
DR BMRB; O27001; -.
DR SMR; O27001; -.
DR STRING; 187420.MTH_916; -.
DR PaxDb; 187420-MTH_916; -.
DR DNASU; 1471324; -.
DR EnsemblBacteria; AAB85414; AAB85414; MTH_916.
DR KEGG; mth:MTH_916; -.
DR HOGENOM; CLU_125807_0_1_2; -.
DR InParanoid; O27001; -.
DR EvolutionaryTrace; O27001; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR Gene3D; 3.30.1190.10; DNA-binding protein Tfx superfamily, archaea; 1.
DR HAMAP; MF_00620; HTH_type_Tfx; 1.
DR InterPro; IPR007630; RNA_pol_sigma70_r4.
DR InterPro; IPR029291; Tfx_C.
DR InterPro; IPR004645; Tfx_DNA-bd_arc.
DR InterPro; IPR018384; Tfx_DNA-bd_euryarc.
DR InterPro; IPR036657; Tfx_DNA-bd_sf_arc.
DR NCBIfam; TIGR00721; tfx; 1.
DR Pfam; PF04545; Sigma70_r4; 1.
DR Pfam; PF14601; TFX_C; 1.
DR PIRSF; PIRSF004932; DNA_bind_Tfx; 1.
DR SUPFAM; SSF89915; DNA-binding protein Tfx; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; DNA-binding; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..138
FT /note="DNA-binding protein Tfx"
FT /id="PRO_0000144167"
FT HELIX 28..33
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 36..38
FT /evidence="ECO:0007829|PDB:1NR3"
FT HELIX 41..46
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 50..53
FT /evidence="ECO:0007829|PDB:1NR3"
FT HELIX 55..62
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 66..70
FT /evidence="ECO:0007829|PDB:1NR3"
FT HELIX 73..75
FT /evidence="ECO:0007829|PDB:1NR3"
FT HELIX 76..90
FT /evidence="ECO:0007829|PDB:1NR3"
FT HELIX 98..108
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 110..112
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 118..120
FT /evidence="ECO:0007829|PDB:1NR3"
FT STRAND 122..135
FT /evidence="ECO:0007829|PDB:1NR3"
SQ SEQUENCE 138 AA; 16083 MW; 76B7B2BB7E45FBE7 CRC64;
MSKKTFLTER QKTVLEMRER GWSQKKIARE LKTTRQNVSA IERKAMENIE KSRNTLDFVK
SLKSPVRILC RRGDTLDEII KRLLEESNKE GIHVIHDSIT LAFLIREKAS HRIVHRVVKS
DFEIGVTRDG EIIVDLNS
//
