ID TIGD2_MOUSE Reviewed; 525 AA.
AC Q0VBL1; Q505P7; Q6NV77;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 116.
DE RecName: Full=Tigger transposable element-derived protein 2;
GN Name=Tigd2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00320,
CC ECO:0000255|PROSITE-ProRule:PRU00583}.
CC -!- SIMILARITY: Belongs to the tigger transposable element derived protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC068272; AAH68272.1; -; mRNA.
DR EMBL; BC094458; AAH94458.1; -; mRNA.
DR EMBL; BC120592; AAI20593.1; -; mRNA.
DR EMBL; BC125491; AAI25492.1; -; mRNA.
DR CCDS; CCDS39500.1; -.
DR RefSeq; NP_001074614.1; NM_001081145.1.
DR AlphaFoldDB; Q0VBL1; -.
DR SMR; Q0VBL1; -.
DR BioGRID; 212677; 1.
DR STRING; 10090.ENSMUSP00000057223; -.
DR iPTMnet; Q0VBL1; -.
DR PhosphoSitePlus; Q0VBL1; -.
DR EPD; Q0VBL1; -.
DR MaxQB; Q0VBL1; -.
DR PaxDb; 10090-ENSMUSP00000057223; -.
DR PeptideAtlas; Q0VBL1; -.
DR ProteomicsDB; 262821; -.
DR Antibodypedia; 65566; 20 antibodies from 11 providers.
DR Ensembl; ENSMUST00000062626.4; ENSMUSP00000057223.4; ENSMUSG00000049232.4.
DR GeneID; 68140; -.
DR KEGG; mmu:68140; -.
DR UCSC; uc009cdj.1; mouse.
DR AGR; MGI:1915390; -.
DR CTD; 166815; -.
DR MGI; MGI:1915390; Tigd2.
DR VEuPathDB; HostDB:ENSMUSG00000049232; -.
DR eggNOG; KOG3105; Eukaryota.
DR GeneTree; ENSGT00940000162273; -.
DR HOGENOM; CLU_018294_1_1_1; -.
DR InParanoid; Q0VBL1; -.
DR OMA; QWFDSQS; -.
DR OrthoDB; 2967227at2759; -.
DR PhylomeDB; Q0VBL1; -.
DR TreeFam; TF101131; -.
DR BioGRID-ORCS; 68140; 1 hit in 76 CRISPR screens.
DR PRO; PR:Q0VBL1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q0VBL1; Protein.
DR Bgee; ENSMUSG00000049232; Expressed in stroma of bone marrow and 225 other cell types or tissues.
DR Genevisible; Q0VBL1; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004875; DDE_SF_endonuclease_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006600; HTH_CenpB_DNA-bd_dom.
DR InterPro; IPR007889; HTH_Psq.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR19303:SF22; TIGGER TRANSPOSABLE ELEMENT-DERIVED PROTEIN 2; 1.
DR PANTHER; PTHR19303; TRANSPOSON; 1.
DR Pfam; PF04218; CENP-B_N; 1.
DR Pfam; PF03184; DDE_1; 1.
DR Pfam; PF03221; HTH_Tnp_Tc5; 1.
DR SMART; SM00674; CENPB; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51253; HTH_CENPB; 1.
DR PROSITE; PS50960; HTH_PSQ; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..525
FT /note="Tigger transposable element-derived protein 2"
FT /id="PRO_0000271089"
FT DOMAIN 1..52
FT /note="HTH psq-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00320"
FT DOMAIN 67..139
FT /note="HTH CENPB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00583"
FT DOMAIN 168..385
FT /note="DDE-1"
FT /evidence="ECO:0000255"
FT DNA_BIND 28..48
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
FT DNA_BIND 100..132
FT /note="H-T-H motif"
FT /evidence="ECO:0000250"
SQ SEQUENCE 525 AA; 59651 MW; 524E3A0BF38E1FFA CRC64;
MLGKRKRVVL TIKDKLDIIK KLEEGNSFKK LSVLYGIGES TVRDIKKNKE RIINYANSSD
PTSGVSKRKS MKSSTYEELD RVMIEWFNQQ KTDGIPVSGT ICAKQARFFF DALGMEGDFN
ASSGWLTRFK QRHGIPKAAG KGTKLKGDET AASEFCGNFQ EFVERENLLP EQIYGADQTG
LFWKCLPTRT LAFDTDQSTC EYRTSRERII IMCCANATGS HKLNLCVVGK AKRPRAFKGT
DLSNLPVTYF SQKSAWIEPS VLKQWFEKCF VPQVQKHLKS KGLREKAVLL LDFPAAHPAE
ELLSSDDGRI IVKYLPPNVT SLIQPMSQGV LTTVKRYYRA GLIQKYMDEG NDPKTFWKNL
TVLDAIYEAS RAWNQIRSNT ITRAWKKLFP GNEENPSVSI DEGAILAANL ATVLQNTEDC
EHVNIENIEQ WFDSRSSGSN CQVLADIVGA ADRAKVTEQK PSRKTRKAEL NPEKHISHKA
ALEWTENLLD YLEQQDDMLL SDKLVLRRLR TIIRRKQRIQ NKSHL
//
