ID TR107_MOUSE Reviewed; 308 AA.
AC Q7M725; Q71QD3;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Taste receptor type 2 member 107;
DE Short=T2R107;
DE Short=mT2R43;
DE AltName: Full=STC5-1;
DE AltName: Full=T2R4;
GN Name=Tas2r107 {ECO:0000312|MGI:MGI:2681207};
GN Synonyms=T2r4 {ECO:0000312|EMBL:AAO14566.1},
GN T2r43 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAO14566.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12920489; DOI=10.1007/s00251-003-0591-8;
RA Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N.,
RA Stoll J., Yokoyama W.M., Brown M.G.;
RT "Molecular genetic characterization of the distal NKC recombination hotspot
RT and putative murine CMV resistance control locus.";
RL Immunogenetics 55:370-378(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAL85198.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 56-273.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [4] {ECO:0000312|EMBL:DAA01211.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors with distinct ligand
CC specificities are expressed in a single taste receptor cell.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF462604; AAO14566.1; -; Genomic_DNA.
DR EMBL; AC140204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF412301; AAL85198.1; -; mRNA.
DR EMBL; BK001072; DAA01211.1; -; Genomic_DNA.
DR CCDS; CCDS20609.1; -.
DR RefSeq; NP_954605.1; NM_199154.2.
DR AlphaFoldDB; Q7M725; -.
DR SMR; Q7M725; -.
DR STRING; 10090.ENSMUSP00000067082; -.
DR GlyCosmos; Q7M725; 3 sites, No reported glycans.
DR GlyGen; Q7M725; 3 sites.
DR PhosphoSitePlus; Q7M725; -.
DR PaxDb; 10090-ENSMUSP00000067082; -.
DR DNASU; 387342; -.
DR Ensembl; ENSMUST00000065781.5; ENSMUSP00000067082.5; ENSMUSG00000053389.5.
DR GeneID; 387342; -.
DR KEGG; mmu:387342; -.
DR UCSC; uc009eiw.1; mouse.
DR AGR; MGI:2681207; -.
DR CTD; 387342; -.
DR MGI; MGI:2681207; Tas2r107.
DR VEuPathDB; HostDB:ENSMUSG00000053389; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M725; -.
DR OMA; CVICIIT; -.
DR OrthoDB; 5306466at2759; -.
DR PhylomeDB; Q7M725; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387342; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q7M725; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M725; Protein.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR CDD; cd15021; 7tm_TAS2R10; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF145; TASTE RECEPTOR TYPE 2 MEMBER 107; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..308
FT /note="Taste receptor type 2 member 107"
FT /id="PRO_0000248252"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 202..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 254..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="I -> L (in Ref. 3; AAL85198)"
FT /evidence="ECO:0000305"
FT CONFLICT 144
FT /note="C -> R (in Ref. 3; AAL85198)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="F -> L (in Ref. 3; AAL85198)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="L -> R (in Ref. 3; AAL85198)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="F -> L (in Ref. 3; AAL85198)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 308 AA; 35427 MW; 3962B4AFC79E4512 CRC64;
MLNSAEGILL CVVTSEAVLG VLGDTYIALF NCMDYAKNKK LSKIGFILIG LAISRIGVVW
IIILQGYIQV FFPHMLTSGN ITEYITYIWV FLNHLSVWFV TNLNILYFLK IANFSNSVFL
WLKRRVNAVF IFLSGCLLTS WLLCFPQMTK ILQNSKMHQR NTSWVHQRKN YFLINQSVTN
LGIFFFIIVS LITCFLLIVF LWRHVRQMHS DVSGFRDHST KVHVKAMKFL ISFMVFFILH
FVGLSIEVLC FILPQNKLLF ITGLTATCLY PCGHSIIVIL GNKQLKQASL KALQQLKCCE
TKGNFRVK
//
