ID TRADD_ONCMY Reviewed; 292 AA.
AC Q1M161;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Tumor necrosis factor receptor type 1-associated DEATH domain protein;
DE Short=TNFR1-associated DEATH domain protein;
DE AltName: Full=TNFRSF1A-associated via death domain protein;
GN Name=tradd;
OS Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8022;
RN [1] {ECO:0000312|EMBL:AAU81663.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Macrophage {ECO:0000269|PubMed:15482855};
RX PubMed=15482855; DOI=10.1016/j.molimm.2004.06.005;
RA Goetz F.W., Iliev D.B., McCauley L.A., Liarte C.Q., Tort L.B., Planas J.V.,
RA Mackenzie S.;
RT "Analysis of genes isolated from lipopolysaccharide-stimulated rainbow
RT trout (Oncorhynchus mykiss) macrophages.";
RL Mol. Immunol. 41:1199-1210(2004).
CC -!- FUNCTION: Adapter molecule for tnfrsf1a that specifically associates
CC with the cytoplasmic domain of activated tnfrsf1a mediating its
CC interaction with fadd. {ECO:0000250|UniProtKB:Q15628}.
CC -!- SUBUNIT: Heterodimer with tnfrsf1a. {ECO:0000250|UniProtKB:Q15628}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3U0V2}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q15628}. Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:Q15628}. Note=Shuttles between the cytoplasm and
CC the nucleus. {ECO:0000250|UniProtKB:Q3U0V2}.
CC -!- DOMAIN: Requires the intact death domain to associate with tnfrsf1a.
CC {ECO:0000250|UniProtKB:Q15628}.
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DR EMBL; AY614596; AAU81663.1; -; mRNA.
DR RefSeq; NP_001118111.1; NM_001124639.1.
DR AlphaFoldDB; Q1M161; -.
DR SMR; Q1M161; -.
DR GeneID; 100136668; -.
DR KEGG; omy:100136668; -.
DR CTD; 8717; -.
DR OrthoDB; 5354303at2759; -.
DR Proteomes; UP000694395; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.30.70.680; TRADD, N-terminal domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR035712; TRADD.
DR InterPro; IPR009095; TRADD_N.
DR InterPro; IPR036729; TRADD_N_sf.
DR PANTHER; PTHR14913; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR14913:SF0; TUMOR NECROSIS FACTOR RECEPTOR TYPE 1-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF09034; TRADD_N; 1.
DR SMART; SM00005; DEATH; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF55044; TRADD, N-terminal domain; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Cytoskeleton; Nucleus.
FT CHAIN 1..292
FT /note="Tumor necrosis factor receptor type 1-associated
FT DEATH domain protein"
FT /id="PRO_0000291661"
FT DOMAIN 199..289
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT MOTIF 148..164
FT /note="Nuclear export signal"
FT /evidence="ECO:0000250"
FT MOTIF 215..228
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
SQ SEQUENCE 292 AA; 32697 MW; 633A27BEFEA7EC86 CRC64;
MVALSVEVGP WTGCAVLFLR SCPAVNLLSL YKDQQGKFSV FKVLKLTLTD SAGGLEGYEI
LKLHDADPLL GVEVKFVDVA ACRRFLQSYG SGAVQQSLSQ HTCRLLHIPQ QELALETQLK
AGTHTLDFCL DDLELCLQHI HQSQPERLRD DEIAELDQQL QSQALGHIPQ PPTLTQEEPP
VPSNCFLFQK RVFEDRMLAA GDLQRFSNGV GRDWRKVGRA LGKNCRALKG PAIDNLAYEY
EREGLYEQAY QLLSRFIQAE GRAARLGRLV RALEDSKLTS LAENILDIQP RD
//
