ID TRPC1_BOVIN Reviewed; 793 AA.
AC O18784; O18785;
DT 20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 08-NOV-2023, entry version 128.
DE RecName: Full=Short transient receptor potential channel 1;
DE Short=TrpC1;
DE AltName: Full=Transient receptor protein 1;
DE Short=TRP-1;
GN Name=TRPC1; Synonyms=TRP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
RC TISSUE=Aorta;
RX PubMed=9357995; DOI=10.1016/s0014-5793(97)01155-1;
RA Chang A.S., Chang S.M., Garcia R.L., Schilling W.P.;
RT "Concomitant and hormonally regulated expression of trp genes in bovine
RT aortic endothelial cells.";
RL FEBS Lett. 415:335-340(1997).
CC -!- FUNCTION: Thought to form a receptor-activated non-selective calcium
CC permeant cation channel. Probably is operated by a phosphatidylinositol
CC second messenger system activated by receptor tyrosine kinases or G-
CC protein coupled receptors. Seems to be also activated by intracellular
CC calcium store depletion.
CC -!- SUBUNIT: Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (By
CC similarity). Interacts with TRPC4 and TRPC5 (By similarity). Interacts
CC with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By
CC similarity). Interacts with FKBP4 (By similarity). Interacts with
CC TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity).
CC {ECO:0000250|UniProtKB:P48995, ECO:0000250|UniProtKB:Q61056,
CC ECO:0000250|UniProtKB:Q9QX01}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Long;
CC IsoId=O18784-1; Sequence=Displayed;
CC Name=Short;
CC IsoId=O18784-2; Sequence=VSP_006559;
CC -!- PTM: Activation of PRKCA induces phosphorylation of TRPC1 and
CC subsequent Ca2+ entry into cells. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. STrpC
CC subfamily. TRPC1 sub-subfamily. {ECO:0000305}.
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DR EMBL; AF012900; AAC48771.1; -; mRNA.
DR EMBL; AF012901; AAC48772.1; -; mRNA.
DR RefSeq; NP_776901.1; NM_174476.2. [O18784-1]
DR AlphaFoldDB; O18784; -.
DR SMR; O18784; -.
DR STRING; 9913.ENSBTAP00000002887; -.
DR PaxDb; 9913-ENSBTAP00000002887; -.
DR GeneID; 282100; -.
DR KEGG; bta:282100; -.
DR CTD; 7220; -.
DR eggNOG; KOG3609; Eukaryota.
DR InParanoid; O18784; -.
DR OrthoDB; 5406916at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0034703; C:cation channel complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR005457; TRPC1_channel.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF56; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR PRINTS; PR01642; TRPCHANNEL1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Calcium; Calcium channel;
KW Calcium transport; Ion channel; Ion transport; Membrane; Phosphoprotein;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..793
FT /note="Short transient receptor potential channel 1"
FT /id="PRO_0000215302"
FT TOPO_DOM 1..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 408..415
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 437..490
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 491..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 512..539
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 540..560
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 561..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608..616
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 617..637
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 638..793
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 46..75
FT /note="ANK 1"
FT REPEAT 83..111
FT /note="ANK 2"
FT REPEAT 112..138
FT /note="ANK 3"
FT REPEAT 158..187
FT /note="ANK 4"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 110..143
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:9357995"
FT /id="VSP_006559"
SQ SEQUENCE 793 AA; 91339 MW; 4A790FA203C0365B CRC64;
MMAALYPSTD LSGASSSSLP SSPSSSSPNE VMALKDVREV KEENTLNEKL FLLACDKGDY
YMVKEILEEN SSGDLNINCV DVLGRNAVTI TIENENLDIL QLLLDYGCQS ADALLVAIDS
EVVGAVDILL NHRPKRSSRP TIVKLMERIQ NPEYSTTMDV APVILAAHRN NYEILTMLLK
QDVSLPKPHA VGCECTLCSA KNKKDSLRHS RFRLDIYRCL ASPALIMLTE EDPILGAFEL
SADLKELSLV EVEFRNDYEE LARQCKMFAK DLLAQARNSR ELEVILNHTS NDEPLDKRGL
LEERMNLSRL KLAIKYNQKE FVSQSNCQQF LNTVWFGQMS GYRRKPTCKK IMTVLTVGIF
WPVLSLCYLI APKSQFGRII HTPFMKFIIH GASYFTFLLL LNLYSLVYHE DKKNTMGPAL
ERIDYLLILW IIGMIWSDIK RLWYEGLEDF LEESRNQLSF VMNSLYLATF ALKEEAHNKF
HDFADRKDWD AFHPTLVAEG LFAFANVLSY LRLFFYVYTS SILGPLQISM GRMLQDFGKF
LGMFLLVLFS FTIGLTQLYD KGYTPKEQKD CVGIFCEQQS NDTFHSFIGT CFALFWYIFS
LAHVAILCTR FSYGEELQSF VGAFIVGTYN VVVVIVLTKL LVAMLHKSFQ LIANHEDKEW
KFARAKLWLS YFDDKCTLPP PFNIIPSPKT ICYMISSLSK WICSHTSKGK VKRQNSLKEW
RHLNEKRDEN YQKVMCCLVR RYLTSMRQKM QSTDQATVEN LNELRQDLSK FRNEIRDLLG
FRTSKYAMFY PRN
//
