ID TUPB_CAMJE Reviewed; 239 AA.
AC Q0P886;
DT 17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Tungstate uptake system permease protein TupB {ECO:0000305};
GN Name=tupB {ECO:0000303|PubMed:19818021};
GN OrderedLocusNames=Cj1539c {ECO:0000312|EMBL:CAL35639.1};
OS Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC
OS 11168).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=192222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=10688204; DOI=10.1038/35001088;
RA Parkhill J., Wren B.W., Mungall K.L., Ketley J.M., Churcher C.M.,
RA Basham D., Chillingworth T., Davies R.M., Feltwell T., Holroyd S.,
RA Jagels K., Karlyshev A.V., Moule S., Pallen M.J., Penn C.W., Quail M.A.,
RA Rajandream M.A., Rutherford K.M., van Vliet A.H.M., Whitehead S.,
RA Barrell B.G.;
RT "The genome sequence of the food-borne pathogen Campylobacter jejuni
RT reveals hypervariable sequences.";
RL Nature 403:665-668(2000).
RN [2]
RP PROBABLE FUNCTION IN TUNGSTATE UPTAKE.
RC STRAIN=ATCC 700819 / NCTC 11168;
RX PubMed=19818021; DOI=10.1111/j.1365-2958.2009.06902.x;
RA Smart J.P., Cliff M.J., Kelly D.J.;
RT "A role for tungsten in the biology of Campylobacter jejuni: tungstate
RT stimulates formate dehydrogenase activity and is transported via an ultra-
RT high affinity ABC system distinct from the molybdate transporter.";
RL Mol. Microbiol. 74:742-757(2009).
CC -!- FUNCTION: Part of an ABC transporter complex involved in ultra-high
CC affinity tungstate uptake. Probably responsible for the translocation
CC of the substrate across the membrane. {ECO:0000305|PubMed:19818021}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (TupC),
CC two transmembrane proteins (TupB) and a solute-binding protein (TupA).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
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DR EMBL; AL111168; CAL35639.1; -; Genomic_DNA.
DR PIR; A81301; A81301.
DR RefSeq; WP_010891942.1; NC_002163.1.
DR RefSeq; YP_002344911.1; NC_002163.1.
DR AlphaFoldDB; Q0P886; -.
DR SMR; Q0P886; -.
DR STRING; 192222.Cj1539c; -.
DR TCDB; 3.A.1.6.11; the atp-binding cassette (abc) superfamily.
DR PaxDb; 192222-Cj1539c; -.
DR EnsemblBacteria; CAL35639; CAL35639; Cj1539c.
DR GeneID; 905821; -.
DR KEGG; cje:Cj1539c; -.
DR PATRIC; fig|192222.6.peg.1516; -.
DR eggNOG; COG4662; Bacteria.
DR HOGENOM; CLU_016047_14_2_7; -.
DR OrthoDB; 9781724at2; -.
DR Proteomes; UP000000799; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; MetI-like; 1.
DR InterPro; IPR049783; ABC_perm_TupB-like.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR NCBIfam; NF038017; ABC_perm1; 1.
DR NCBIfam; NF041773; tung_perm_TupB; 1.
DR PANTHER; PTHR43632; PERMEASE COMPONENT OF TUNGSTATE ABC TRANSPORTER; 1.
DR PANTHER; PTHR43632:SF1; PERMEASE COMPONENT OF TUNGSTATE ABC TRANSPORTER; 1.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; MetI-like; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..239
FT /note="Tungstate uptake system permease protein TupB"
FT /id="PRO_0000435509"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 37..233
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 239 AA; 26419 MW; 9F684BAB4262050D CRC64;
MLKLLILKRI FLDYIFDGFK QALFLLFNAD ESVISAIKTT LLSSSISIVL ALLIGFPLGF
ILGFFEFKLK RFIKLIVDTS LSFPTVAVGL ILYALISSRG PLGEFGLLFT IKALILGQFI
LALPIVIALF SNLIENMNKK HFLLIKSFHL SPLKLVLTMI YELRFALISV VALAYGRIVA
EVGVAMIVGG NIKYDTRTIT TAISLETNKG EFASGIALAL VLILIAFCLN FITHKLKRT
//
