ID   U1FM06_TRESO            Unreviewed;       516 AA.
AC   U1FM06;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Spiro-SPASM protein {ECO:0000313|EMBL:ERF60461.1};
GN   ORFNames=HMPREF1325_1504 {ECO:0000313|EMBL:ERF60461.1};
OS   Treponema socranskii subsp. socranskii VPI DR56BR1116 = ATCC 35536.
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=1125725 {ECO:0000313|EMBL:ERF60461.1, ECO:0000313|Proteomes:UP000016412};
RN   [1] {ECO:0000313|EMBL:ERF60461.1, ECO:0000313|Proteomes:UP000016412}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VPI DR56BR1116 {ECO:0000313|EMBL:ERF60461.1,
RC   ECO:0000313|Proteomes:UP000016412};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA   Methe B., Sutton G., Nelson K.E.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERF60461.1}.
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DR   EMBL; AUZJ01000042; ERF60461.1; -; Genomic_DNA.
DR   AlphaFoldDB; U1FM06; -.
DR   STRING; 1125725.HMPREF1325_1504; -.
DR   PATRIC; fig|1125725.3.peg.1517; -.
DR   eggNOG; COG0535; Bacteria.
DR   OrthoDB; 335556at2; -.
DR   Proteomes; UP000016412; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd01335; Radical_SAM; 1.
DR   CDD; cd21109; SPASM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR007197; rSAM.
DR   InterPro; IPR027608; Spiro_SPASM.
DR   NCBIfam; TIGR04321; spiroSPASM; 1.
DR   PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR   PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   Pfam; PF13186; SPASM; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT   DOMAIN          231..457
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
SQ   SEQUENCE   516 AA;  57416 MW;  2825FA41BD3E58EA CRC64;
     MMKTVVILNA AFGARYMFEK VFGGRSAYDR ALSWAASVSG GTPVIVLAAS DNAERCKREA
     VSSSVPVSVK EKEVWTTADV LDEIASLSEK AETVLYAAAD CPFFDKALSD EILRVHKTYA
     AEYTFADGYP YGFSPEAIDT GAAAIIASLA RQKNLGDEVV TRDAVMKILK TDINSFEIET
     VLAPKDWRLY RLSFECSTKA GYIASRALYD ACGEGKDAAS LSEKAVTLVS VLKTVPAFYN
     VQISGREEGE CIYSPYREAY KKTYGEKNPR DMTLAEFRPL VSQMASLSES AVVSLSAWGE
     PLLHPDFTDF VKETASYDGL SILVETNGLH VTEELCEKVK EASGGKIIWI VLLDAVSEAT
     YKKMRGSEGS LSKAHKAVAL LQRAFPDTTY PQFVRTNDNE AELEAFYRFW KDDKNGSKVI
     IQKYDWFSGL LPECKPADLS PLERNPCWHL RRDMTILSDG SVPPCREYVF NNIIGNAFTE
     SLASIWERMT SYAEKDMKCE YGEVCGKCDE YYTFNF
//