ID U1I026_ENDPU Unreviewed; 573 AA.
AC U1I026;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN ORFNames=EPUS_05823 {ECO:0000313|EMBL:ERF76550.1};
OS Endocarpon pusillum (strain Z07020 / HMAS-L-300199) (Lichen-forming
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Verrucariales; Verrucariaceae; Endocarpon.
OX NCBI_TaxID=1263415 {ECO:0000313|EMBL:ERF76550.1, ECO:0000313|Proteomes:UP000019373};
RN [1] {ECO:0000313|Proteomes:UP000019373}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z07020 / HMAS-L-300199 {ECO:0000313|Proteomes:UP000019373};
RX PubMed=24438332; DOI=10.1186/1471-2164-15-34;
RA Wang Y.-Y., Liu B., Zhang X.-Y., Zhou Q.-M., Zhang T., Li H., Yu Y.-F.,
RA Zhang X.-L., Hao X.-Y., Wang M., Wang L., Wei J.-C.;
RT "Genome characteristics reveal the impact of lichenization on lichen-
RT forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota).";
RL BMC Genomics 15:34-34(2014).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR EMBL; KE720743; ERF76550.1; -; Genomic_DNA.
DR RefSeq; XP_007786074.1; XM_007787884.1.
DR AlphaFoldDB; U1I026; -.
DR GeneID; 19240770; -.
DR eggNOG; KOG0436; Eukaryota.
DR HOGENOM; CLU_009710_9_0_1; -.
DR OMA; MDTQAFC; -.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000019373; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000019373}.
FT DOMAIN 43..411
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 573 AA; 65852 MW; 9A16B258BD6D25F3 CRC64;
MSILERQARV FFQLSRASKG SRTWRRCCQS ASPNPSKQKP KPYYVTTPIF YVNAAPHVGH
LYTFVLADIL KRWALLRGDR SAVMLTGTDE HGMKVQRAAQ KAKTDTKLFC DQTMLQFDRL
ARKANISYDR FIRTTDPDHK EAVQHFWREL SHRGYIYESK HEGWYSVSDE TFFPPSAVHL
IRDPATGRKI MVSKETGREV EWTSETNYHF KLSAFRYRLL RLYDDNPAFV VPATRMNHVI
QEVKKGLEDL SISRPAERLT WGIRVPNDDS QTIYVWLDAL VNYLTQAGYP FADRTGSGTE
WPPDVQVIGK DITKFHCIYW PAFLMALNLP LPKQILTHAH WTMNHAKMSK STGNVVNPFF
AIDRFEVDTV RFYMAYDGGI ADDTDYDNAY IIERYKKLLQ GGIGNLASRI MRGKRWSVHE
CVRYGAGQDL EAEPLGKDHR TRLAKLQAQV QHQFMTLNPR EALHHIMDVL ALTNKFITHN
AVWRIVNDPN EKAQRDVKII IYYAAESLRI CGILLQPFMP SKMERLLDML GVDETSRNYG
HARLGRDLSY GIPKADLGAG ADTSLFPPLT SEL
//
