ID U1JMK0_9GAMM Unreviewed; 825 AA.
AC U1JMK0;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=PCIT_14159 {ECO:0000313|EMBL:ERG17885.1};
OS Pseudoalteromonas citrea DSM 8771.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Pseudoalteromonadaceae; Pseudoalteromonas.
OX NCBI_TaxID=1117314 {ECO:0000313|EMBL:ERG17885.1, ECO:0000313|Proteomes:UP000016487};
RN [1] {ECO:0000313|EMBL:ERG17885.1, ECO:0000313|Proteomes:UP000016487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 8771 {ECO:0000313|Proteomes:UP000016487};
RX PubMed=22535931; DOI=10.1128/JB.00265-12;
RA Xie B.B., Shu Y.L., Qin Q.L., Rong J.C., Zhang X.Y., Chen X.L., Shi M.,
RA He H.L., Zhou B.C., Zhang Y.Z.;
RT "Genome sequences of type strains of seven species of the marine bacterium
RT Pseudoalteromonas.";
RL J. Bacteriol. 194:2746-2747(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERG17885.1}.
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DR EMBL; AHBZ02000147; ERG17885.1; -; Genomic_DNA.
DR AlphaFoldDB; U1JMK0; -.
DR STRING; 1117314.PCIT_14159; -.
DR eggNOG; COG0286; Bacteria.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000016487; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ERG17885.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000016487};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERG17885.1}.
FT DOMAIN 9..149
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 177..490
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 825 AA; 93613 MW; DC1061EA2E44A821 CRC64;
MDHSAHNKLI SFIWSIADDC LRDVYVRGKY RDVILPMVVL RRLDTLLEPT KKAVLDEVKF
QVEEMEATEL DDAPLIDAAG YVFYNTSKWT LTSIKETATN NRQIILANIE EYLNGFSANV
KEIIECFNLK SQFQHMAGKD VLLDVLEKFV SPTINLTPDE VEDPEGNKLP ALSNLGMGYV
FEELIRKFNE DNNEEAGEHF TPREVIELMT HLVFDPIKSD LPLTLTVYDP ACGSGGMLTE
TQNFINENYP VENTTRDINL YGKEINDETY AICKSDMMIK GNDPKNIKVG STLSTDEFAG
QRFDFCLSNP PYGKSWASEQ KHIKEGSDVI DSRFQVVLKD YWGNLPKEGF VDATPRSSDG
QLLFLMEMVS KMKSIATSPL GSRIASVHNG SSLFTGDAGS GESNIRRYII ENDMLDAIVQ
LPNNLFYNTG ITTYIWLLNN SKPDQRKGKV QLIDASLLFK KLRKNLGNKN CEFSPEHITE
ITQTYLDAAS VERQLTQEKG PTGIAAKVFN NDDFGYYKVN IERPDRRSAQ FKDDLIAPLR
FDKTLREPME HLYVEYGDKV YQADFFTADN KAMEKDVIAW CEDNDINLNA KAKAKLLATD
TWLNGKLLVE LANKLAETII AEYNDYNLFK ADVEAQFKQI SADVLADIKP NKRKAFYITV
VNAMSWYDEN AEKVIKKVVK FKQDKLDELL HHLGCEQAGS LSEVMADFGY YAIEDKKLEF
TTYESNSDLR DAESVPLTYN EGNDSDNSEI HQYFLDEVQP HVSEAWINLD STKIGYEISF
NKYFYQHKPL RAMDEVATDI INLEQKAEGL IADILGVDIA KVHGA
//
