ID U1R196_9EURY Unreviewed; 755 AA.
AC U1R196;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=DNA mismatch repair protein MutS {ECO:0000313|EMBL:ERH13448.1};
DE Flags: Fragment;
GN ORFNames=J07HB67_02488 {ECO:0000313|EMBL:ERH13448.1};
OS halophilic archaeon J07HB67.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales.
OX NCBI_TaxID=1085029 {ECO:0000313|EMBL:ERH13448.1};
RN [1] {ECO:0000313|EMBL:ERH13448.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23637883;
RA Podell S., Ugalde J.A., Narasingarao P., Banfield J.F., Heidelberg K.B.,
RA Allen E.E.;
RT "Assembly-driven community genomics of a hypersaline microbial ecosystem.";
RL PLoS ONE 8:E61692-E61692(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE356582; ERH13448.1; -; Genomic_DNA.
DR AlphaFoldDB; U1R196; -.
DR STRING; 1085029.J07HB67_02488; -.
DR HOGENOM; CLU_002472_3_1_2; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 681..697
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 487..528
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 755
FT /evidence="ECO:0000313|EMBL:ERH13448.1"
SQ SEQUENCE 755 AA; 81589 MW; 537818E93329FB01 CRC64;
MTTAEGIVGE FMSLKRETAA DLLTMQCGDF YEFFGEDAET VADELDLKVS QKSAHGSSYP
MAGVPVDDLR PYLGSLVERG YRVAVADQYE TSDGHARRVQ RVVSPGTVLD PDDAAARYLA
AVVREGDGYG LAFADVTTGQ FRAGRVTDAQ AATAQLHRFD PVELLPGPEA RADDPVVDRV
AEGDTTVTLH DTAAFAPGRA RHRLTDQFGE TALDAVGLTA EPAVAAAGAI LAYVETTGVG
VTASMTRLGA LDAGDRVTLD ATTRRNLELV ETMQGGSEGT LLATVDHTET AAGSRLLREW
LTAPTRDRGE IRRRHDAVEA LADAALARDR LRELLSGVAD LERLAARATN GSADPRALGA
VRTALGLMPE LAAAVADTPL ADGPVADVLA TPDQTAAREL YETLDAALVA EPTRPGEGVI
ARGHDTELDE VVADYQETRE WLDGLADRET RRHGLRHVTV DRNKTDGYYI QVGKSAADEV
PDHYRQIKTL KNSVRFLTDD LAEREREMLR LEERREQLET ELFADLRERV AADAELLQTV
GRTLAELDTL ASLATHAATA DWVRPDLSSD RELDVTAGRH PVVERTTEFV PNDLRMDDDR
GFLIVTGPNM SGKSTYMRQC ALLVLLAQAG SFVPAESATV PVVDGVYTRV GALDELAQGR
STFMVEMQEL SNILHSATRD SLVVLDEVGR GTATYDGISI AWAATEYLHN EVRAKTLFAT
HYHELTTLGD TLPRVQNVHV AVDDAGEHVT SSAGC
//
