ID U1R5Q7_9ACTO Unreviewed; 671 AA.
AC U1R5Q7;
DT 13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203};
GN ORFNames=HMPREF1980_01167 {ECO:0000313|EMBL:ERH28884.1};
OS Actinomyces sp. oral taxon 172 str. F0311.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=1321775 {ECO:0000313|EMBL:ERH28884.1, ECO:0000313|Proteomes:UP000016501};
RN [1] {ECO:0000313|EMBL:ERH28884.1, ECO:0000313|Proteomes:UP000016501}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0311 {ECO:0000313|EMBL:ERH28884.1,
RC ECO:0000313|Proteomes:UP000016501};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERH28884.1}.
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DR EMBL; AWSF01000098; ERH28884.1; -; Genomic_DNA.
DR RefSeq; WP_021611224.1; NZ_KE952157.1.
DR AlphaFoldDB; U1R5Q7; -.
DR STRING; 1321775.HMPREF1980_01167; -.
DR PATRIC; fig|1321775.3.peg.995; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_1_1_11; -.
DR OrthoDB; 9804933at2; -.
DR Proteomes; UP000016501; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..544
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
SQ SEQUENCE 671 AA; 74374 MW; 8B5DE12A9724E5E9 CRC64;
MADPSTYRPR TGDIPTSPGV YRFSDPHGRV IYVGKAKNLR NRLTNYFQDL ANLHPRTQQM
VTTASAVQWT VVRSEVEALT LEFTWIKEFN PRFNVMFKDD KSYPYLAVSM GERFPRVQVT
RERKRAGSRY FGPYTQVWAI RDTIDQLLRV FPMRSCSAGV FQRAKAQGRP CLLGYIDKCA
APCVGRISME EHRELAEELC QFMEGRTGPV IRDLEEQMRQ ASAELNFERA AKLRDDVKAL
RTVLERNAVV LDDGSDADVF SLVSDDLDAA VYVFHVRGGR IRGTRGWVIE RVDGAGDEAL
MSRLLEQVYS SASMDEAGAG SATKVAAVSV DDVAHTPTSA IPREVLVSVE PEEKETIARW
LAQIRGASVS IHVPKRGPKA QLMETVTENA RQGLALHRTK RAGDITARSK ALEQLAENLD
LPGAPLRIEC YDVSHTGGEN QVASMVVFED GMPRKDAYRT YNIRGEDGNG TPDDTSAMNE
VLTRRFSRLL AEEAGVKGED EDGVAFASGP IDETTGRPKR FSYRPDLVVV DGGLPQVNAA
RAALDAVGAD VPVVGLAKRL EEVWIPGDEF PLILPRTSEA LYLLQYLRDE SHRFAITKHR
KRRSKAQRRS VLDSIPGLGP ARQAALLKHF GSVKRIREAS LEQIAEVKGV GPALAASIRD
RLAASSREDT P
//
